Diep My, Cassarino David S
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA; and.
Department of Pathology, Southern California Permanente Medical Group, Sunset Medical Center, Los Angeles, CA.
Am J Dermatopathol. 2020 Jan;42(1):52-54. doi: 10.1097/DAD.0000000000001489.
Epidermal inclusion cyst (EIC) and syringoma are both benign lesions that are primarily asymptomatic and occur at various places on the body. Although both EIC and syringoma are common, their joint appearance has not been previously reported. These benign proliferations target different populations, and with differing clinical presentations. Syringomas tend to develop in young females as smaller multiple lesions, while EICs often present in older males as single or multiple variants that are typically larger in size. They also possess distinctive histopathological appearances that can used for their diagnosis. Furthermore, despite both having unclear etiologies, the involvement of the eccrine duct has been a proposed mechanism in the development of both lesions. Thus, further investigation of eccrine ducts in the pathology of these lesions can be the basis for assessing the association between EICs and syringomas. We report a unique case of a 16-year-old boy who presented to the clinic with multiple cysts (at least 20) on the scrotum, most of which consisted of both EIC and syringoma histologically. We are not aware of any previous reports of patients with multiple combined syringomas and EICs, and their potential association should be further explored.
表皮样囊肿（EIC）和汗管瘤均为良性病变，主要无症状，可发生于身体的不同部位。虽然EIC和汗管瘤都很常见，但它们同时出现的情况此前未见报道。这些良性增生针对不同人群，临床表现也有所不同。汗管瘤往往在年轻女性中出现，为较小的多发性病变，而EIC常出现在老年男性中，表现为单个或多个病变，通常体积较大。它们还具有独特的组织病理学表现，可用于诊断。此外，尽管两者病因均不明，但小汗腺导管的参与被认为是这两种病变发生的一种机制。因此，对这些病变病理学中小汗腺导管的进一步研究可以作为评估EIC与汗管瘤之间关联的基础。我们报告了一例独特病例，一名16岁男孩因阴囊出现多个囊肿（至少20个）前来就诊，其中大多数在组织学上同时包含EIC和汗管瘤成分。我们未发现此前有关于多发性汗管瘤和EIC合并存在的患者的报道，其潜在关联值得进一步探索。
