Department of Experimental Psychology, University of Oxford, Oxford, UK.
Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland.
J Pineal Res. 2019 Nov;67(4):e12602. doi: 10.1111/jpi.12602. Epub 2019 Aug 22.
In humans, the production of melatonin is suppressed by light exposure. This effect is mediated by a retinal pathway involving the melanopsin-containing intrinsincally photosensitive retinal ganglion cells (ipRGCs), which exhibit maximum sensitivity to short-wavelength light. Here, based on extant and published data, we examine how signals from the two eyes are integrated in driving the suppression of melatonin by light. We find that melatonin suppression by light exposure to two eyes corresponds to a sensitivity shift by about 1.2 log units (factor ~17.4).
在人类中，光照会抑制褪黑素的产生。这种效应是通过一条包含含有黑素小体的 intrinsically photosensitive retinal ganglion cells（ipRGCs）的视网膜通路介导的，这些细胞对短波长光具有最大的敏感性。在这里，我们基于现有的和已发表的数据，研究了来自两只眼睛的信号如何整合来驱动光对褪黑素的抑制。我们发现，两只眼睛受到光照抑制褪黑素的敏感性变化约为 1.2 个对数单位（约为 17.4 倍）。
