Rea Mark S, Nagare Rohan, Figueiro Mariana G
Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, United States.
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Neurosci. 2021 Feb 5;15:615322. doi: 10.3389/fnins.2021.615322. eCollection 2021.
A revised computational model of circadian phototransduction is presented. The first step was to characterize the spectral sensitivity of the retinal circuit using suppression of the synthesis of melatonin by the pineal gland at night as the outcome measure. From the spectral sensitivity, circadian light was defined. Circadian light, thereby rectifies any spectral power distribution into a single, instantaneous photometric quantity. The second step was to characterize the circuit's response characteristic to different amounts of circadian light from threshold to saturation. By doing so a more complete instantaneous photometric quantity representing the circadian stimulus was defined in terms of both the spectral sensitivity and the response magnitude characteristic of the circadian phototransduction circuit. To validate the model of the circadian phototransduction circuit, it was necessary to augment the model to account for different durations of the circadian stimulus and distribution of the circadian stimulus across the retina. Two simple modifications to the model accounted for the duration and distribution of continuous light exposure during the early biological night. A companion paper (https://www.frontiersin.org/articles/10.3389/fnins.2020.615305/full) provides a neurophysiological foundation for the model parameters.
本文提出了一种经修订的昼夜节律光转导计算模型。第一步是以夜间松果体褪黑素合成的抑制作为结果指标，来表征视网膜回路的光谱敏感性。根据光谱敏感性定义了昼夜节律光。昼夜节律光从而将任何光谱功率分布校正为一个单一的瞬时光度学量。第二步是表征该回路对从阈值到饱和的不同量昼夜节律光的响应特性。通过这样做，根据昼夜节律光转导回路的光谱敏感性和响应幅度特性，定义了一个更完整的代表昼夜节律刺激的瞬时光度学量。为了验证昼夜节律光转导回路模型，有必要对模型进行扩充，以考虑昼夜节律刺激的不同持续时间以及昼夜节律刺激在视网膜上的分布。对模型的两个简单修改考虑了生物夜间早期连续光照的持续时间和分布。一篇配套论文（https://www.frontiersin.org/articles/10.3389/fnins.2020.615305/full）为模型参数提供了神经生理学基础。
