新型pendrin抑制剂可减轻实验性小鼠哮喘中的气道高反应性和黏蛋白表达。 - Suppr

Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma.

作者信息

Park Jinhong, Lee Hyun Jae, Song Doona, Gi Mia, Jo Sungwoo, Jeon Dong-Kyu, Seo Yohan, Kim Bomin, Lee Ho, Namkung Wan, Han Gyoonhee, Choi Jae Young

机构信息

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea; Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, Korea.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

出版信息

J Allergy Clin Immunol. 2019 Nov;144(5):1425-1428.e12. doi: 10.1016/j.jaci.2019.07.016. Epub 2019 Jul 27.

DOI:10.1016/j.jaci.2019.07.016

PMID:31362010

Abstract

摘要

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Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma.新型pendrin抑制剂可减轻实验性小鼠哮喘中的气道高反应性和黏蛋白表达。

J Allergy Clin Immunol. 2019 Nov;144(5):1425-1428.e12. doi: 10.1016/j.jaci.2019.07.016. Epub 2019 Jul 27.

Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways.糖皮质激素对白细胞介素-13诱导的小鼠气道嗜酸性粒细胞增多、高反应性和杯状细胞增生的差异调节作用。

Am J Respir Crit Care Med. 2003 Jan 1;167(1):50-6. doi: 10.1164/rccm.2110084.

Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.雷公藤内酯醇通过 NF-κB 抑制哮喘小鼠气道杯状细胞增生和 Muc5ac 表达。

Mol Immunol. 2015 Mar;64(1):99-105. doi: 10.1016/j.molimm.2014.11.001. Epub 2014 Nov 21.

Niflumic acid suppresses interleukin-13-induced asthma phenotypes.尼氟灭酸可抑制白细胞介素-13诱导的哮喘表型。

Am J Respir Crit Care Med. 2006 Jun 1;173(11):1216-21. doi: 10.1164/rccm.200410-1420OC. Epub 2006 Mar 9.

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.鉴定Pendrin作为支气管哮喘和慢性阻塞性肺疾病中黏液产生的共同介质。

J Immunol. 2008 May 1;180(9):6262-9. doi: 10.4049/jimmunol.180.9.6262.

Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression.轻度和中度哮喘与气道杯状细胞增生及黏蛋白基因表达异常有关。

Am J Respir Crit Care Med. 2001 Feb;163(2):517-23. doi: 10.1164/ajrccm.163.2.2004039.

Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.变应性哮喘小鼠模型中杯状细胞和黏蛋白基因表达的时间分析。

Exp Lung Res. 2003 Dec;29(8):549-65. doi: 10.1080/01902140390240159.

Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls.鼻窦炎患儿与对照组鼻窦黏膜中MUC5AC黏蛋白表达的免疫组织化学分析。

Ann Otol Rhinol Laryngol. 2005 Dec;114(12):958-65. doi: 10.1177/000348940511401212.

Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice.甜茶罗汉果残余提取物通过下调 IL-4、IL-5、IL-13、IL-17 和 MUC5AC 的表达来减轻卵清蛋白诱导的小鼠肺部炎症。

Phytomedicine. 2019 Aug;61:152835. doi: 10.1016/j.phymed.2019.152835. Epub 2019 Jan 16.

Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways.Muc-5/5ac黏蛋白信使核糖核酸和蛋白质表达是小鼠气道杯状细胞化生的一个标志物。

Am J Respir Cell Mol Biol. 2000 Mar;22(3):253-60. doi: 10.1165/ajrcmb.22.3.3768.

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Solute Carrier Family 26 Member 4 (SLC26A4), A Potential Therapeutic Target for Asthma.溶质载体家族26成员4（SLC26A4），哮喘的一个潜在治疗靶点。

J Respir Biol Transl Med. 2024 Jun;1(2). doi: 10.35534/jrbtm.2024.10011. Epub 2024 Jun 25.

Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium.聚焦碳酸氢盐：气道上皮细胞中CFTR校正的药理学见解

Front Pharmacol. 2023 Dec 11;14:1293578. doi: 10.3389/fphar.2023.1293578. eCollection 2023.

SLC26 Anion Transporters.SLC26 阴离子转运蛋白。

Handb Exp Pharmacol. 2024;283:319-360. doi: 10.1007/164_2023_698.

A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH.点头与WNK（激酶）：了解气道表面液体pH值

Am J Respir Cell Mol Biol. 2022 Oct;67(4):421-422. doi: 10.1165/rcmb.2022-0285ED.

Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells.功能性特异性白介素-17A 和地塞米松在原代人呼吸道上皮细胞中的相互作用。

Sci Rep. 2022 Jun 30;12(1):11110. doi: 10.1038/s41598-022-15393-2.

Role of SLC4 and SLC26 solute carriers during oxidative stress.SLC4 和 SLC26 溶质载体在氧化应激中的作用。

Acta Physiol (Oxf). 2022 May;235(1):e13796. doi: 10.1111/apha.13796. Epub 2022 Mar 1.

Chloride transport modulators as drug candidates.氯离子转运调节剂作为药物候选物。

Am J Physiol Cell Physiol. 2021 Dec 1;321(6):C932-C946. doi: 10.1152/ajpcell.00334.2021. Epub 2021 Oct 13.

Type II alveolar epithelial cell-specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4.II 型肺泡上皮细胞特异性 RhoA 缺失通过 SLC26A4 加重过敏性气道炎症。

JCI Insight. 2021 Jul 22;6(14):e148147. doi: 10.1172/jci.insight.148147.

Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury.小分子抑制 Pendrin 可减轻脂多糖诱导的急性肺损伤。

Theranostics. 2020 Aug 7;10(22):9913-9922. doi: 10.7150/thno.46417. eCollection 2020.

Phenotype-Specific Therapeutic Effect of var. Combined with Dexamethasone on Experimental Murine Asthma and Its Comprehensive Pharmacological Mechanism.var. 联合地塞米松对实验性哮喘的表型特异性治疗作用及其综合药理学机制。

Int J Mol Sci. 2019 Aug 28;20(17):4216. doi: 10.3390/ijms20174216.

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Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma.

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