National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Control Release. 2019 Sep 10;309:203-219. doi: 10.1016/j.jconrel.2019.07.036. Epub 2019 Jul 27.
Nanocarriers sensitive to near infrared light (NIR) are useful templates for chemo-photothermal therapy (PTT) and imaging of tumors due to the ability to change the absorbed NIR energy to heat. The conventional photo-absorbing reagents lack the efficient loading and release of drug before reaching the target site leading to insufficient therapeutic outcomes. To overcome these limitations, the surface of nanocarriers can be modified with different polymers with wide functionalities to provide systems with diagnostic, therapeutic, and theranostic capabilities. Among various polymers, polydopamine (PDA) has been more interested due to complex structure with various chemical moieties, and the capacity to be used through different coating mechanism. In this review, we describe the complex structure, chemical properties, and coating mechanisms of PDA. Moreover, the advantage and surface modification of some relevant nanosystems based on carbon materials, gold, iron oxide, manganese, and upconverting nanomaterials by using PDA will be discussed, in detail.
基于近红外光（NIR）的纳米载体由于能够将吸收的 NIR 能量转化为热能，因此是用于肿瘤化学-光热治疗（PTT）和成像的有用模板。传统的光吸收试剂在到达靶位之前缺乏有效的药物加载和释放，导致治疗效果不足。为了克服这些限制，可以用具有广泛功能的不同聚合物对纳米载体的表面进行修饰，为系统提供诊断、治疗和治疗诊断能力。在各种聚合物中，由于具有复杂的结构和各种化学部分，并且可以通过不同的涂层机制使用，因此聚多巴胺（PDA）受到了更多的关注。在这篇综述中，我们描述了 PDA 的复杂结构、化学性质和涂层机制。此外，还详细讨论了一些相关纳米系统的优势和表面改性，这些纳米系统基于碳材料、金、氧化铁、锰和上转换纳米材料，并使用 PDA。
