CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology , Beijing 100190 , P.R. China.
Department of Chemistry , Tsinghua University , Beijing 100084 , P.R. China.
ACS Nano. 2019 Apr 23;13(4):4379-4391. doi: 10.1021/acsnano.8b09607. Epub 2019 Mar 26.
Combining informative imaging methodologies with effective treatments to destroy tumors is of great importance for oncotherapy. Versatile nanotheranostic agents that inherently possess both diagnostic imaging and therapeutic capabilities are highly desirable to meet these requirements. Here, a simple but powerful nanoplatform based on polydopamine-coated gold nanostar (GNS@PDA), which can be easily diversified to achieve various function extensions, is designed to realize functional and anatomical imaging-guided photothermal oncotherapy. This nanoplatform intrinsically enables computed tomography/photoacoustic/two-photon luminescence/infrared thermal tetramodal imaging and can further incorporate fibroblast activation protein (FAP, a protease highly expressed in most of tumors) activatable near-infrared fluorescence imaging and Fe-based magnetic resonance imaging for comprehensive diagnosis. Moreover, GNS@PDA exhibits excellent photothermal performance and efficient tumor accumulation. Under the precise guidance of multimodal imaging, GNS@PDA conducts homogeneous photothermal ablation of bulky solid tumors (∼200 mm) in a xenograft mouse model. These results suggest great promise of this extendable nanoplatform for cancer theranostics.
将信息丰富的成像方法与有效的肿瘤破坏治疗相结合，对于肿瘤治疗至关重要。多功能的纳米诊疗剂，固有地具有诊断成像和治疗能力，非常符合这些要求。在这里，设计了一种基于聚多巴胺包覆的金纳米星（GNS@PDA）的简单但强大的纳米平台，该平台可以轻松多样化以实现各种功能扩展，以实现功能和解剖成像引导的光热肿瘤治疗。该纳米平台固有地能够进行计算机断层扫描/光声/双光子荧光/红外热四模态成像，并可进一步整合成纤维母细胞激活蛋白（FAP，在大多数肿瘤中高度表达的一种蛋白酶）激活的近红外荧光成像和基于 Fe 的磁共振成像，以进行全面诊断。此外，GNS@PDA 表现出优异的光热性能和高效的肿瘤积累。在多模态成像的精确指导下，GNS@PDA 在异种移植小鼠模型中对体积较大的实体瘤（约 200mm）进行均匀的光热消融。这些结果表明，这种可扩展的纳米平台在癌症治疗中有很大的应用前景。
