School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Biomed Pharmacother. 2019 Oct;118:109195. doi: 10.1016/j.biopha.2019.109195. Epub 2019 Jul 27.
Current evidences suggest that hyperuricemia is closely related to the overproduction or underexcretion of uric acid (UA). Curcumin (CUR), a natural polyphenol component extracted from the rhizome of Curcuma longa, has been reported to treat various symptoms such inflammation disease, seems to be efficacious in hyperuricemia. In this study, we aimed to investigate the effect of CUR on hyperuricemia and kidney inflammation in hyperuricemic mice. Administration with CUR (20 or 40 mg/kg) or allopurinol (ALL, 5 mg/kg) was given to mice orally one hour later after the injection of potassium oxonate (PO) (300 mg/kg, i.p.) for 14 days. CUR administration decreased the levels of uric acid (UA), creatinine (CRE) and blood urea nitrogen (BUN) in serum. Meanwhile, treatment with CUR effectively inhibited serum and liver xanthine oxidase (XOD) levels, and further renewed normal antioxidant enzymes activities (SOD, GSH-Px), reduced MDA accumulation in serum. Further studies showed that CUR decreased inflammatory cytokines productions (IL-1β, IL-18) in serum, as well as inhibited PO-induced the activation of NLRP3 inflammasome signaling in the kidney. In conclusion, the study revealed that CUR exhibited anti-hyperuricemic and anti-inflammatory effects through suppressing NLRP3 inflammasome activation in kidney and provided the evidence for treating hyperuricemia and associated renal inflammation.
目前的证据表明，高尿酸血症与尿酸（UA）的产生过多或排泄不足密切相关。姜黄素（CUR）是从姜黄根茎中提取的天然多酚成分，已被报道可治疗各种炎症疾病，似乎对高尿酸血症有效。在这项研究中，我们旨在研究 CUR 对高尿酸血症小鼠高尿酸血症和肾脏炎症的影响。在腹腔注射氧嗪酸钾（PO）（300mg/kg）1 小时后，给予 CUR（20 或 40mg/kg）或别嘌醇（ALL，5mg/kg）口服治疗 14 天。CUR 给药降低了血清中尿酸（UA）、肌酐（CRE）和血尿素氮（BUN）的水平。同时，CUR 治疗有效抑制了血清和肝脏黄嘌呤氧化酶（XOD）水平，并进一步恢复了正常抗氧化酶活性（SOD、GSH-Px），减少了血清中 MDA 的积累。进一步的研究表明，CUR 降低了血清中炎性细胞因子的产生（IL-1β、IL-18），并抑制了 PO 诱导的肾脏中 NLRP3 炎性小体信号的激活。总之，该研究表明，CUR 通过抑制肾脏中 NLRP3 炎性小体的激活，表现出抗高尿酸血症和抗炎作用，为治疗高尿酸血症和相关的肾脏炎症提供了证据。
