Tanaka Kouichi, Miki Takashi, Murata Kunihiko, Yamaguchi Ayumi, Kayaki Yoshihito, Kuwata Shigeki, Ikariya Takao, Watanabe Masahito
Central Research Laboratory, Technology & Development Division , Kanto Chemical Co., Inc. , 7-1, Inari 1-chome , Soka-city , Saitama 340-0003 , Japan.
Department of Chemical Science and Engineering, School of Materials and Chemical Technology , Tokyo Institute of Technology , 2-12-1-E4-1 O-okayama , Meguro-ku, Tokyo 152-8552 , Japan.
J Org Chem. 2019 Sep 6;84(17):10962-10977. doi: 10.1021/acs.joc.9b01565. Epub 2019 Aug 9.
Cp*Ir complexes bearing a 2-picolinamide moiety serve as effective catalysts for the direct reductive amination of ketonic compounds to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source. The clean and operationally simple transformation proceeds with a substrate to catalyst molar ratio (S/C) of up to 20,000 at relatively low temperature and exhibits excellent chemoselectivity toward primary amines.
带有2-吡啶甲酰胺部分的Cp*Ir配合物可作为有效的催化剂，在转移氢化条件下，以甲酸铵作为氮源和氢源，将酮类化合物直接还原胺化生成伯胺。这种清洁且操作简单的转化反应在相对较低温度下，底物与催化剂的摩尔比（S/C）高达20,000时仍能进行，并且对伯胺表现出优异的化学选择性。
