Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
Clin Exp Hypertens. 2020;42(3):281-286. doi: 10.1080/10641963.2019.1649683. Epub 2019 Jul 30.
Hypertension is a common clinical problem, and increased aldosterone is the most prevalent underlying characteristic. Related works have shown exciting results on the effects of various conditions on aldosterone content, but the correlation between aldosterone levels and body mass index (BMI) in premenopausal women has not yet been investigated. We herein report a cross-sectional analysis aimed to determine whether BMI is proportional to plasma aldosterone concentration in premenopausal and postmenopausal hypertensive women. The analysis of consecutive admitted female patients with hypertension revealed potential relationships among plasma aldosterone concentration, plasma renin activity, oestrogen, and BMI. It should be noted that plasma aldosterone concentration was significantly correlated with BMI ( < .05) in postmenopausal women, and both plasma aldosterone and oestrogen levels were decreased in premenopausal women. These findings suggest that BMI has a positive impact on aldosterone in postmenopausal hypertensive women but not in premenopausal women. Additionally, we predict that endogenous oestrogen may be an important indication of aldosterone changes in premenopausal hypertensive women of different body weights.
高血压是一种常见的临床问题，其中醛固酮增多是最常见的潜在特征。相关研究已经表明，各种情况对醛固酮含量的影响具有令人兴奋的结果，但尚未研究绝经前妇女的醛固酮水平与体重指数（BMI）之间的关系。本研究旨在确定绝经前和绝经后高血压女性的 BMI 是否与血浆醛固酮浓度成正比，进行了一项横断面分析。对连续入院的女性高血压患者进行分析，揭示了血浆醛固酮浓度、血浆肾素活性、雌激素和 BMI 之间的潜在关系。值得注意的是，绝经后女性的血浆醛固酮浓度与 BMI 呈显著正相关（<0.05），而绝经前女性的血浆醛固酮和雌激素水平均降低。这些发现表明，BMI 对绝经后高血压女性的醛固酮有积极影响，但对绝经前女性没有影响。此外，我们预测内源性雌激素可能是不同体重的绝经前高血压女性醛固酮变化的一个重要指标。
