Fujii R, Meguro H, Nishimura T, Kobayashi Y, Haruta T, Toyonaga Y, Okada T, Furukawa S, Kitamura I, Ogura H
Department of Pediatrics, School of Medicine, Teikyo University.
Jpn J Antibiot. 1988 Apr;41(4):390-8.
A monotherapy of aztreonam (AZT) was applied to 9 male and 3 female pediatric patients of ages ranging from 2 months to 8 years and 11 months with serious purulent meningitis. The results are summarized as follows: 1. Daily dosages of 134 to 400 mg/kg were given 3 to 4 times a day for 10 to 28 days. 2. The isolated pathogens were Neisseria meningitidis in 2 cases, Escherichia coli in 3 cases, Haemophilus influenzae in 6 cases, but the pathogen of the last case was unknown. In this case, the patient had myelomeningocele and suffered from recurrent purulent meningitis. 3. Clinical effect was "excellent" in 5 of 12 cases, "good" in 7 cases and efficacy rate was 100%. Microbiological tests were performed on 9 cases during the course of treatment and bacterial elimination rate was 100%. All the pathogens were eliminated in 72 hours. 4. One case of diarrhea was observed, but the diarrhea started before the administration of AZT and was stopped after the AZT treatment. A slight elevation of GOT value was observed in 1 case but the value returned to the initial level promptly after the treatment was completed. It is considered that AZT is highly useful for purulent meningitis caused by Gram-negative pathogens such as H. influenzae, E. coli and N. meningitidis.
对9名男性和3名女性、年龄在2个月至8岁11个月之间患有严重化脓性脑膜炎的儿科患者采用氨曲南（AZT）单一疗法进行治疗。结果总结如下：1. 每日剂量为134至400mg/kg，每天给药3至4次，持续10至28天。2. 分离出的病原体中，2例为脑膜炎奈瑟菌，3例为大肠杆菌，6例为流感嗜血杆菌，但最后1例患者的病原体不明。该患者患有脊髓脊膜膨出并反复发生化脓性脑膜炎。3. 12例患者中5例临床效果为“优”，7例为“良”，有效率为100%。治疗过程中对9例患者进行了微生物检测，细菌清除率为100%。所有病原体均在72小时内被清除。4. 观察到1例腹泻，但腹泻在给予AZT之前就已开始，AZT治疗后停止。1例患者观察到谷草转氨酶（GOT）值略有升高，但治疗结束后该值迅速恢复到初始水平。认为AZT对由流感嗜血杆菌、大肠杆菌和脑膜炎奈瑟菌等革兰氏阴性病原体引起的化脓性脑膜炎非常有用。
