Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
Curr Alzheimer Res. 2019;16(7):633-649. doi: 10.2174/1567205016666190726100744.
Mild Parkinsonian Signs (MPS) have been associated with Mild Cognitive Impairment (MCI) types with conflicting results.
To investigate the association of individual MPS with different MCI types using logistic ridge regression analysis, and to evaluate for each MCI type, the association of MPS with caudate atrophy, global cerebral atrophy, and the topographical location of White Matter Hyperintensities (WMH), and lacunes.
A cross-sectional study was performed among 1,168 subjects with different types of MCI aged 45-97 (70,52 ± 9,41) years, who underwent brain MRI. WMH were assessed through two visual rating scales. The number and location of lacunes were also rated. Atrophy of the caudate nuclei and global cerebral atrophy were assessed through the bicaudate ratio, and the lateral ventricles to brain ratio, respectively. Apolipoprotein E (APOE) genotypes were also assessed. Using the items of the motor section of the Unified Parkinson's Disease Rating Scale, tremor, rigidity, bradykinesia, and gait/balance/axial dysfunction were evaluated.
Bradykinesia, and gait/balance/axial dysfunction were the MPS more frequently encountered followed by rigidity, and tremor. MPS were present in both amnestic and non-amnestic MCI types, and were associated with WMH, lacunes, bicaudate ratio, and lateral ventricles to brain ratio.
MPS are present in both amnestic and non-amnestic MCI types, particularly in those multiple domain, and carrying the APOE ε4 allele. Cortical and subcortical vascular and atrophic processes contribute to MPS. Long prospective studies are needed to disentangle the contribution of MPS to the conversion from MCI to dementia.
轻度帕金森氏症（MPS）与轻度认知障碍（MCI）类型相关，但结果存在冲突。
使用逻辑岭回归分析研究个体 MPS 与不同 MCI 类型的关联，并评估每种 MCI 类型中 MPS 与尾状核萎缩、全脑萎缩以及脑白质高信号（WMH）和腔隙的拓扑位置之间的关联。
对年龄在 45-97 岁（70.52±9.41 岁）之间患有不同类型 MCI 的 1168 名受试者进行了一项横断面研究，这些受试者均接受了脑部 MRI 检查。WMH 通过两种视觉评分量表进行评估。腔隙的数量和位置也进行了评分。尾状核和全脑萎缩分别通过双尾核比和侧脑室与脑比进行评估。还评估了载脂蛋白 E（APOE）基因型。使用统一帕金森病评定量表的运动部分项目评估震颤、僵直、运动迟缓以及步态/平衡/轴性功能障碍。
运动迟缓以及步态/平衡/轴性功能障碍是最常出现的 MPS，其次是僵直和震颤。MPS 存在于遗忘型和非遗忘型 MCI 类型中，与 WMH、腔隙、双尾核比和侧脑室与脑比相关。
MPS 存在于遗忘型和非遗忘型 MCI 类型中，特别是在多域和携带 APOE ε4 等位基因的患者中。皮质和皮质下血管及萎缩过程促成了 MPS。需要进行长期前瞻性研究来阐明 MPS 对从 MCI 向痴呆转化的贡献。
