一种用于活细胞中 Zn 成像的高选择性和高灵敏度的 1,8-萘酰亚胺基荧光传感器。
A highly selective and sensitive 1,8-naphthalimide-based fluorescent sensor for Zn imaging in living cells.
机构信息
College of Basic Science, Chemistry Experiment Teaching Center, Tianjin Agricultural University, Tianjin, China; Department of Chemistry, Department of Biochemistry and Molecular Biology, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin, China.
College of Basic Science, Chemistry Experiment Teaching Center, Tianjin Agricultural University, Tianjin, China.
出版信息
Bioorg Med Chem Lett. 2019 Sep 15;29(18):2646-2649. doi: 10.1016/j.bmcl.2019.07.046. Epub 2019 Jul 24.
A new 4-amino-1,8-naphthalimide-based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn in aqueous solution and living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn with about 7-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1,8-naphthalimide with a green color centered at 550 nm.
开发了一种新型基于 4-氨基-1,8-萘二甲酰亚胺的荧光传感器，其受体为亚氨乙酸和亚氨乙醚乙酸。该传感器成功应用于检测水溶液和活细胞中的 Zn。在生理 pH 条件下，它对 Zn 的检测具有高选择性和灵敏度，在水溶液中约有 7 倍的增强，其特征发射带为 4-氨基-1,8-萘二甲酰亚胺，呈绿色，中心位于 550nm。
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