Bečulić Hakija, Skomorac Rasim, Jusić Aldin, Alić Fahrudin, Mašović Anes, Burazerović Eldin, Omerhodžić Ibrahim, Dorić Mirsad, Imamović Melica, Mekić-Abazović Alma, Efendić Alma, Udovčić-Gagula Dalma
1Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina; 2Department of Neurosurgery, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina; 3Institute of Pathology, Medical Faculty of Sarajevo, Sarajevo, Bosnia and Herzegovina; 4Department of Emergency Medicine, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina; 5Department of Oncology and Radiotherapy, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina; 6Department of Radiology, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina; 7Institute of Pathology, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina.
Acta Clin Croat. 2019 Mar;58(1):42-49. doi: 10.20471/acc.2019.58.01.06.
The aim of the study was to analyze correlation between morphological characteristics of intracranial meningiomas and Ki67 labeling index (Ki67 LI), and their influence on peritumoral brain edema (PTBE). There were 41 consecutive patients with intracranial meningiomas surgically treated at the Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina, during the period from January 2010 to December 2015. We reviewed clinical data including patient age, gender, magnetic resonance imaging (MRI) characteristics of the tumor and peritumoral edema, tumor margins, intraoperative characteristics, histopathologic grade and Ki67 LI. In all cases, follow up MRI was obtained at about three months after resection and PTBE was analyzed. Our research showed the tumor volume, tumor margins, and intraoperative signs of arachnoidal and pial invasion to be associated with PTBE in intracranial meningiomas. Ki67 LI expression correlated with PTBE. This study showed the resolution of PTBE to depend on invasive behavior of meningioma and KI67 LI. PTBE, pial/cortical and arachnoidal invasion significantly influence the extent of surgical resection.
本研究旨在分析颅内脑膜瘤的形态学特征与Ki67标记指数（Ki67 LI）之间的相关性，以及它们对瘤周脑水肿（PTBE）的影响。2010年1月至2015年12月期间，波斯尼亚和黑塞哥维那泽尼察州立医院神经外科对41例连续的颅内脑膜瘤患者进行了手术治疗。我们回顾了临床资料，包括患者年龄、性别、肿瘤及瘤周水肿的磁共振成像（MRI）特征、肿瘤边界、术中特征、组织病理学分级和Ki67 LI。所有病例均在切除术后约三个月进行随访MRI检查，并分析PTBE。我们的研究表明，肿瘤体积、肿瘤边界以及蛛网膜和软脑膜侵犯的术中征象与颅内脑膜瘤的PTBE相关。Ki67 LI表达与PTBE相关。本研究表明，PTBE的消退取决于脑膜瘤的侵袭行为和KI67 LI。PTBE、软脑膜/皮质和蛛网膜侵犯显著影响手术切除范围。
Zotero 插件
