钙的罪魁祸首：一例地诺单抗诱发的低钙血症病例。
The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia.
作者信息
Kalayanamitra Ricci, Yaghnam Ibrahim, Patel Ravi, Groff Andrew, Jain Rohit
机构信息
Emergency Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
出版信息
Cureus. 2019 May 28;11(5):e4768. doi: 10.7759/cureus.4768.
Abstract
Denosumab is a fully human monoclonal antibody which is used to treat osteoporosis and has been shown to cause hypocalcemia in patients with underlying prostatic and bone malignancies, renal impairment, postmenopausal state, and/or vitamin D deficiency. We present a case of a male patient, with a past medical history negative for the aforementioned conditions, who presented with right shoulder pain and was found to be severely hypocalcemic secondary to denosumab.
摘要
地诺单抗是一种全人源单克隆抗体，用于治疗骨质疏松症，已被证明会导致患有潜在前列腺癌和骨恶性肿瘤、肾功能损害、绝经后状态和/或维生素D缺乏的患者出现低钙血症。我们报告一例男性患者，既往病史中无上述情况，因右肩疼痛就诊，发现因使用地诺单抗继发严重低钙血症。
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