化疗引起的周围神经病（CIPN）的生物学预测因子：MASCC 神经并发症工作组概述。
Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview.
机构信息
National University of Singapore, Singapore, Singapore.
National Cancer Centre Singapore, Singapore, Singapore.
出版信息
Support Care Cancer. 2019 Oct;27(10):3729-3737. doi: 10.1007/s00520-019-04987-8. Epub 2019 Jul 30.
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in the development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As a drug response can vary between individuals, it is hypothesized that an individual's specific genetic variants could impact the regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review was to summarize the known biological (molecular and genomic) predictors of CIPN and discuss the means to facilitate progress in this field.
摘要
化疗引起的周围神经病（CIPN）是一种常见的、使人虚弱的疾病，与许多化疗药物有关。通常与 CIPN 发展有关的药物包括铂类药物、紫杉烷类、长春碱类生物碱、硼替佐米和沙利度胺类似物。由于个体之间的药物反应可能有所不同，因此有人假设个体的特定遗传变异可能会影响参与药物药代动力学、离子通道功能、神经毒性和 DNA 修复的基因的调节，从而影响 CIPN 的发展和严重程度。其他分子标记物的变异也可能影响 CIPN 的发生率和严重程度。因此，本综述的目的是总结已知的 CIPN 的生物学（分子和基因组）预测因子，并讨论促进该领域进展的方法。
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