Wang Xianshu, Pan Hongyan, Lin Qian, Wu Hong, Jia Shuangzhu, Shi Yongyong
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, Guizhou, People's Republic of China.
Key Laboratory of Green Chemical and Clean Energy Technology, Guiyang, 550025, Guizhou, People's Republic of China.
Nanoscale Res Lett. 2019 Jul 30;14(1):259. doi: 10.1186/s11671-019-3075-y.
In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m/g), narrowly pore size distribution (2.01-3.65 nm), and high nitrogen content (4.75-6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: q > q > q > q. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g) and higher dissolution rate (93.75%).
采用喷雾干燥和碳化技术相结合的一步法制备了具有不同碳硅比（C/Si）（NMCs-x/3，x = 5、6、7和8）的原位氮掺杂亲水性介孔碳球，其中三嵌段共聚物（F127）和正硅酸四乙酯（TEOS）用作模板剂，生物相容性壳聚糖（CS）用作碳源和氮源。通过热重分析（TG）、比表面积分析仪（BET）、X射线衍射仪（XRD）、拉曼光谱仪、傅里叶变换红外光谱仪（FTIR）、透射电子显微镜（TEM）、X射线光电子能谱仪（XPS）和接触角测量仪对这些碳材料进行了表征。研究了介孔碳材料对难溶性抗肿瘤药物羟基喜树碱（HCPT）的吸附和释放性能。结果表明，成功制备了具有高比表面积（2061.6 m²/g）、窄孔径分布（2.01 - 3.65 nm）和高氮含量（4.75 - 6.04%）的纳米球形介孔碳材料。那些NMCs-x表现出令人满意的亲水性，其随着表面氮含量的增加而逐渐增加。并且NMCs-x的亲水性越好，对HCPT的吸附容量越大。NMCs-x对HCPT的吸附容量顺序为：q₈ > q₇ > q₆ > q₅。NMCs-5/3对HCPT具有最大的饱和吸附容量（1013.51 mg/g）和较高的溶解率（93.75%）。
