a Department of Pharmaceutics , School of Pharmacy, Shenyang Pharmaceutical University , Shenyang , PR China.
b School of Chinese Materia Medica, Department of Chinese Medicinal Pharmaceutics , Beijing university of Chinese Medicine , Beijing , PR China.
Drug Deliv. 2017;24(sup1):94-107. doi: 10.1080/10717544.2017.1399300.
Recent development of nano-technology provides highly efficient and versatile treatment methods to achieve better therapeutic efficacy and lower side effects of malignant cancer. The exploration of drug delivery systems (DDSs) based on nano-material shows great promise in translating nano-technology to clinical use to benefit patients. As an emerging inorganic nanomaterial, mesoporous carbon nanomaterials (MCNs) possess both the mesoporous structure and the carbonaceous composition, endowing them with superior nature compared with mesoporous silica nanomaterials and other carbon-based materials, such as carbon nanotube, graphene and fullerene. In this review, we highlighted the cutting-edge progress of carbon nanomaterials as drug delivery systems (DDSs), including immediate/sustained drug delivery systems and controlled/targeted drug delivery systems. In addition, several representative biomedical applications of mesoporous carbon such as (1) photo-chemo synergistic therapy; (2) delivery of therapeutic biomolecule and (3) in vivo bioimaging are discussed and integrated. Finally, potential challenges and outlook for future development of mesoporous carbon in biomedical fields have been discussed in detail.
近年来，纳米技术的发展为实现更好的治疗效果和更低的恶性癌症副作用提供了高效、多功能的治疗方法。基于纳米材料的药物传递系统（DDS）的探索在将纳米技术转化为临床应用以造福患者方面显示出巨大的前景。作为一种新兴的无机纳米材料，介孔碳纳米材料（MCN）具有介孔结构和碳质组成，与介孔硅纳米材料和其他碳基材料（如碳纳米管、石墨烯和富勒烯）相比，具有优越的性质。在这篇综述中，我们重点介绍了碳纳米材料作为药物传递系统（DDS）的最新进展，包括即时/持续药物传递系统和控制/靶向药物传递系统。此外，还讨论并整合了介孔碳在（1）光化疗协同治疗；（2）治疗生物分子的输送；（3）体内生物成像等几个代表性的生物医学应用。最后，详细讨论了介孔碳在生物医学领域未来发展的潜在挑战和展望。
