全身[F]FDG-PET/MRI 与 [F]FDG-PET/CT 对比在恶性黑色素瘤中的应用。
Whole-Body [F]FDG-PET/MRI vs. [F]FDG-PET/CT in Malignant Melanoma.
机构信息
Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Vienna, Austria.
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
出版信息
Mol Imaging Biol. 2020 Jun;22(3):739-744. doi: 10.1007/s11307-019-01413-7.
PURPOSE
To assess the diagnostic performance of simultaneous whole-body 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron emission tomography (PET)/magnetic resonance imaging (MRI) compared to [F]FDG PET/x-ray computed tomography (CT) for detection of distant metastatic disease in patients with malignant melanoma.
PROCEDURES
We included patients with malignant melanoma who underwent a single injection [F]FDG dual-imaging protocol that included whole-body PET/CT and subsequent whole-body PET/MRI for staging or restaging purposes in a prospective setting. Images from both modalities were analyzed by two rater teams for the presence of metastatic lesions. PET/CT-PET/MRI overall agreement as well as region-based accuracies, sensitivities (Se), and specificities (Sp) were computed.
RESULTS
Between July 2014 and December 2018, 22 patients were enrolled. Interrater agreement and overall accuracy (consensus reading) were 78.8 % (95 % CI 71-84.9) and 96.1 % (95 % CI 92.3-98) for PET/MRI and 78 % (70.2-84.3) and 97.4 % (95 % CI 93.7-98.9) for PET/CT, respectively (P = 0.42). PET/MRI reached a region-based Se of 89.1 % (95 % CI 79.4-94.5) and a Sp of 100 %, whereas PET/CT showed a region-based Se of 92.7 % (95 % CI 84-96.9) and a Sp of 100 % for the detection of metastatic disease in malignant melanoma.
CONCLUSIONS
Whole-body [F]FDG-PET/MRI appears to be comparable to [F]FDG-PET/CT for lesion detection in patients with malignant melanoma.
目的
评估同时进行全身 2-脱氧-2-[F]氟-D-葡萄糖 ([F]FDG) 正电子发射断层扫描 (PET)/磁共振成像 (MRI) 与 [F]FDG PET/ X 射线计算机断层扫描 (CT) 相比，在检测恶性黑色素瘤患者远处转移疾病方面的诊断性能。
方法
我们纳入了在前瞻性环境下接受单次全身 [F]FDG 双成像方案的恶性黑色素瘤患者，该方案包括全身 PET/CT 和随后的全身 PET/MRI 用于分期或重新分期。由两个评分小组分析两种模式的图像是否存在转移性病变。计算了 PET/CT-PET/MRI 的总体一致性以及基于区域的准确性、敏感性 (Se) 和特异性 (Sp)。
结果
在 2014 年 7 月至 2018 年 12 月期间，共纳入 22 名患者。PET/MRI 的观察者间一致性和总体准确性（共识阅读）分别为 78.8%（95%CI 71-84.9）和 96.1%（95%CI 92.3-98），而 PET/CT 分别为 78%（70.2-84.3）和 97.4%（95%CI 93.7-98.9）（P=0.42）。PET/MRI 的区域特异性 Se 达到 89.1%（95%CI 79.4-94.5），Sp 为 100%，而 PET/CT 对恶性黑色素瘤转移疾病的区域特异性 Se 为 92.7%（95%CI 84-96.9），Sp 为 100%。
结论
全身 [F]FDG-PET/MRI 似乎与 [F]FDG-PET/CT 相比，在检测恶性黑色素瘤患者的病变方面具有可比性。
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