Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Breast Cancer Res Treat. 2019 Nov;178(1):199-205. doi: 10.1007/s10549-019-05369-8. Epub 2019 Jul 30.
To assess the association between benign ovarian tumors and subsequent risk of breast cancer, and to examine this association according to type of benign ovarian tumors.
This nationwide cohort study comprised all Danish women diagnosed with a benign ovarian tumor during 1978-2016 (n = 158,221) identified through the Danish National Patient Register. The cohort was linked to the Danish Cancer Registry to identify all cases of breast cancer, and standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated.
Overall, women with a benign ovarian tumor were at significantly increased risk of breast cancer. The risk was confined to women with a solid ovarian tumor (SIR 1.09; 95% CI 1.05-1.13), particularly in women ≥ 50 years at benign tumor diagnosis (SIR 1.19; 95% CI 1.12-1.26). The risk remained increased up to 20 years or more after the diagnosis of a solid ovarian tumor (SIR 1.11; 95% CI 1.04-1.18), and women with a solid tumor were at increased risk of ductal, lobular, and other types of breast cancer, although most consistent for the lobular subtype. For cystic tumors, this association was confined to ductal breast cancer in women with the tumor diagnosed at age ≥ 50 years.
Women with a benign ovarian tumor were at increased risk of breast cancer. This association was largely confined to women with a solid ovarian tumor, and the excess risk was present 20 years or more after the ovarian tumor diagnosis. The underlying mechanism is unknown and should be investigated further.
评估良性卵巢肿瘤与随后乳腺癌风险之间的关联，并根据良性卵巢肿瘤的类型来研究这种关联。
本全国性队列研究纳入了 1978 年至 2016 年期间在丹麦被诊断为良性卵巢肿瘤的所有女性（n=158221），通过丹麦国家患者登记处确定。该队列与丹麦癌症登记处相关联，以确定所有乳腺癌病例，并计算标准化发病比（SIR）和 95%置信区间（CI）。
总体而言，患有良性卵巢肿瘤的女性患乳腺癌的风险显著增加。这种风险仅限于患有实性卵巢肿瘤的女性（SIR 1.09；95%CI 1.05-1.13），尤其是在良性肿瘤诊断时年龄≥50 岁的女性（SIR 1.19；95%CI 1.12-1.26）。在诊断出实性卵巢肿瘤后 20 年或更长时间内，风险仍然增加（SIR 1.11；95%CI 1.04-1.18），并且患有实性肿瘤的女性患有导管性、小叶性和其他类型的乳腺癌的风险增加，尽管小叶性亚型最为一致。对于囊性肿瘤，这种关联仅限于年龄≥50 岁的女性诊断出的导管性乳腺癌。
患有良性卵巢肿瘤的女性患乳腺癌的风险增加。这种关联主要局限于患有实性卵巢肿瘤的女性，并且在卵巢肿瘤诊断后 20 年或更长时间存在额外的风险。潜在的机制尚不清楚，应进一步调查。
