Singapore General Hospital, Singapore, Singapore.
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Adv Exp Med Biol. 2019;1145:105-116. doi: 10.1007/978-3-030-16373-0_8.
In the last decade, considerable advancements have been made to identify the pharmacokinetic/pharmacodynamic (PK/PD) index that defines the antimicrobial activity of polymyxins. Dose-fractionation studies performed in hollow-fiber models found that altering the dosing schedule had little impact on the killing or suppression of resistance emergence, alluding to AUC/MIC as the pharmacodynamic index that best describes polymyxin's activity. For in vivo efficacy, the PK/PD index that was the most predictive of the antibacterial effect of colistin against P. aeruginosa and A. baumannii was ƒAUC/MIC.
在过去的十年中，人们在确定能够定义多黏菌素类药物抗菌活性的药代动力学/药效学（PK/PD）指标方面取得了相当大的进展。在中空纤维模型中进行的剂量分割研究发现，改变给药方案对杀菌或抑制耐药性产生的影响很小，这表明 AUC/MIC 是最能描述多黏菌素类药物活性的药效学指标。对于体内疗效，预测多黏菌素对铜绿假单胞菌和鲍曼不动杆菌的抗菌作用的 PK/PD 指标是 ƒAUC/MIC。
