疑似原发性肾淋巴瘤犬的临床特征及预后

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma.

作者信息

Taylor A, Finotello R, Vilar-Saavedra P, Couto C G, Benigni L, Lara-Garcia A

机构信息

Royal Veterinary College, University of London, Hertfordshire, AL9 7TA, UK.

Institute of Veterinary Science, University of Liverpool, Liverpool, L69 3GH, UK.

出版信息

J Small Anim Pract. 2019 Nov;60(11):663-670. doi: 10.1111/jsap.13059. Epub 2019 Jul 31.

DOI:10.1111/jsap.13059

PMID:31364180

Abstract

OBJECTIVES

To characterise the presentation, clinicopathologic data and outcome of 29 dogs with presumed primary renal lymphoma.

MATERIALS AND METHODS

Retrospective analysis of medical records of dogs with suspected primary renal lymphoma from 11 institutions.

RESULTS

All dogs were substage b, and lethargy and gastrointestinal signs were common presenting complaints, as were azotaemia (n=25; 86%) and erythrocytosis (n=15; 51%) on biochemical testing. Ultrasonography typically revealed bilateral renal lesions (n=23; 79%), renomegaly (n=22; 76%) and abdominal lymphadenopathy (n=14; 48%). Chemotherapy was the only treatment in 23 dogs, of which 11 responded, all considered partial responses. For all dogs the median progression-free survival and median overall survival times were 10 days (range: 1 to 126) and 12 days (range: 1 to 212), respectively, and for dogs that responded to chemotherapy 41 days (range: 10 to 126) and 47 days (range: 10 to 212), respectively.

CLINICAL SIGNIFICANCE

Primary renal lymphoma in dogs appears to be associated with a poor prognosis and short-lived response to chemotherapy.

摘要

目的

对29只疑似原发性肾淋巴瘤犬的临床表现、临床病理数据及预后进行特征描述。

材料与方法

对来自11家机构的疑似原发性肾淋巴瘤犬的病历进行回顾性分析。

结果

所有犬均为b期亚分期，嗜睡和胃肠道症状是常见的主诉，生化检测时氮质血症（n = 25；86%）和红细胞增多症（n = 15；51%）也较为常见。超声检查通常显示双侧肾脏病变（n = 23；79%）、肾肿大（n = 22；76%）和腹部淋巴结病（n = 14；48%）。23只犬仅接受了化疗，其中11只产生反应，均为部分反应。所有犬的无进展生存期和总生存期的中位数分别为10天（范围：1至126天）和12天（范围：1至212天），对化疗有反应的犬的无进展生存期和总生存期的中位数分别为41天（范围：10至126天）和47天（范围：10至212天）。