Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.
J Biol Rhythms. 2019 Oct;34(5):451-462. doi: 10.1177/0748730419863917. Epub 2019 Jul 31.
Most visual system functions, such as opsin gene expression, retinal neural transmission, light perception, and visual sensitivity, display robust day-night rhythms. The rhythms persist in constant lighting conditions, suggesting the involvement of endogenous circadian clocks. While the circadian pacemakers that control the rhythms of animal behaviors are mostly found in the forebrain and midbrain, self-sustained circadian oscillators are also present in the neural retina, where they play important roles in the regulation of circadian vision. This review highlights some of the correlative studies of the circadian control of visual system functions in zebrafish. Because zebrafish maintain a high evolutionary proximity to mammals, the findings from zebrafish research may provide insights for a better understanding of the mechanisms of circadian vision in other vertebrate species including humans.
大多数视觉系统功能，如视蛋白基因表达、视网膜神经传递、光感知和视觉灵敏度，都显示出强大的昼夜节律。这些节律在持续光照条件下仍然存在，表明内源性生物钟的参与。虽然控制动物行为节律的昼夜节律起搏器主要存在于前脑和中脑，但自主的昼夜节律振荡器也存在于神经视网膜中，它们在调节昼夜视觉中发挥着重要作用。本综述强调了一些关于斑马鱼视觉系统功能昼夜节律控制的相关研究。由于斑马鱼与哺乳动物保持着高度的进化亲缘关系，因此斑马鱼研究的结果可能为更好地理解包括人类在内的其他脊椎动物物种的昼夜视觉机制提供一些启示。
