不同的视角：尿 pH 值在前列腺癌诊断中重要吗？

A different perspective: Can urine pH be important in the diagnosis of prostate cancer?

机构信息

Department of Urology, Clinic of Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.

出版信息

Urologia. 2020 Feb;87(1):19-22. doi: 10.1177/0391560319865724. Epub 2019 Jul 31.

DOI:10.1177/0391560319865724

PMID:31364489

Abstract

OBJECTIVE

The aim of our study was to investigate emphasis of urinary pH in patients with prostate cancer.

METHODS

Patients, who underwent 12-core prostate biopsy because of prostate-specific antigen elevation and suspicious digital rectal examination, were retrospectively reviewed. According to pathology, patients with prostate cancer were classified as group 1, and patients with benign prostatic hyperplasia were classified as group 2. Primary endpoint of this study was the urine pH. The age of two groups and urine pH were compared with each other. Student t test and Mann-Whitney U test were used for the intergroup analysis of continuous variables. A cut-off value for urine pH was determined with a receiver operating characteristic curve. p < 0.05 was considered as statistically significant.

RESULTS

There were 119 patients in group 1 and 99 patients in group 2. When urine pHs of both groups were compared, group 1 and group 2 were 5.1 ± 0.45 and 5.5 ± 0.79, respectively (p = 0.0001). The cut-off value determined by receiver operating characteristic curve analysis for urine pH was 5.2 (sensitivity: 42%, specificity: 79%, area under the curve: 0.61; 95% CI: [0.53, 0.68]; p = 0.003).

CONCLUSION

Acidic urine pH may be important for predicting prostate cancer according to this study.

摘要

目的

本研究旨在探讨前列腺癌患者尿液 pH 值的侧重点。

方法

回顾性分析因前列腺特异性抗原升高和直肠指诊可疑而接受 12 针前列腺活检的患者。根据病理结果，将前列腺癌患者分为第 1 组，将良性前列腺增生患者分为第 2 组。本研究的主要终点是尿 pH 值。比较两组的年龄和尿 pH 值。使用 Student t 检验和 Mann-Whitney U 检验对两组的连续变量进行组间分析。通过受试者工作特征曲线确定尿 pH 值的临界值。p<0.05 被认为具有统计学意义。

结果

第 1 组有 119 例患者，第 2 组有 99 例患者。比较两组的尿 pH 值，第 1 组和第 2 组分别为 5.1±0.45 和 5.5±0.79（p=0.0001）。通过受试者工作特征曲线分析确定的尿 pH 值临界值为 5.2（敏感性：42%，特异性：79%，曲线下面积：0.61；95%CI：[0.53，0.68]；p=0.003）。