China National Clinical Research Center for Respiratory Diseases,Department of Respiratory Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China.
Epidemiol Infect. 2019 Jan;147:e192. doi: 10.1017/S0950268819000839.
Paediatric Mycoplasma pneumoniae pneumonia (MPP) is a major cause of community-acquired pneumonia in China. Data on epidemiology of paediatric MPP from China are little known. This study retrospectively collected data from June 2006 to June 2016 in Beijing Children's Hospital, Capital Medical University of North China and aims to explore the epidemiological features of paediatric MPP and severe MPP (SMPP) in North China during the past 10 years. A total of 27 498 paediatric patients with pneumonia were enrolled. Among them, 37.5% of paediatric patients had MPP. In this area, an epidemic took place every 2-3 years at the peak, and the positive rate of MPP increased during these peak years over time. The peak age of MPP was between the ages of 6 and 10 years, accounting for 75.2%, significantly more compared with other age groups (χ2 = 1384.1, P < 0.0001). The epidemics peaked in September, October and November (χ2 = 904.9, P < 0.0001). Additionally, 13.0% of MPP paediatric patients were SMPP, but over time, the rate of SMPP increased, reaching 42.6% in 2016. The mean age of paediatric patients with SMPP (6.7 ± 3.0 years old) was younger than that of patients with non-SMPP (7.4 ± 3.2 years old) (t = 3.60, P = 0.0001). The prevalence of MPP and SMPP is common in China, especially in children from 6 to 10 years old. Paediatric patients with SMPP tend to be younger than those with non-SMPP. MPP outbreaks occur every 2-3 years in North China. September, October and November are the peak months, unlike in South China. Understanding the epidemiological characteristics of paediatric MPP can contribute to timely treatment and diagnosis, and may improve the prognosis of children with SMPP.
儿童肺炎支原体肺炎（MPP）是中国社区获得性肺炎的主要病因。关于中国儿童 MPP 的流行病学数据鲜为人知。本研究回顾性收集了 2006 年 6 月至 2016 年 6 月期间华北地区首都医科大学附属北京儿童医院的数据，旨在探讨过去 10 年华北地区儿童 MPP 和重症 MPP（SMPP）的流行病学特征。共纳入 27498 例肺炎患儿，其中 37.5%的患儿患有 MPP。在该地区，每隔 2-3 年就会出现一次流行高峰，且在这些高峰年份中，MPP 的阳性率呈逐渐上升趋势。MPP 的发病高峰年龄在 6-10 岁之间，占 75.2%，明显高于其他年龄组（χ2=1384.1，P＜0.0001）。流行高峰出现在 9 月、10 月和 11 月（χ2=904.9，P＜0.0001）。此外，13.0%的 MPP 患儿为 SMPP，但随着时间的推移，SMPP 的比例逐渐增加，2016 年达到 42.6%。SMPP 患儿的平均年龄（6.7±3.0 岁）小于非 SMPP 患儿（7.4±3.2 岁）（t=3.60，P=0.0001）。中国儿童 MPP 和 SMPP 的患病率较高，尤其是 6-10 岁儿童。SMPP 患儿的年龄普遍小于非 SMPP 患儿。华北地区每隔 2-3 年发生一次 MPP 暴发。流行高峰在 9、10 和 11 月，与华南地区不同。了解儿童 MPP 的流行病学特征有助于及时治疗和诊断，可能改善 SMPP 患儿的预后。
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