兔葡萄糖代谢的F-19磁共振成像

F-19 MR imaging of glucose metabolism in the rabbit.

作者信息

Nakada T, Kwee I L, Griffey B V, Griffey R H

机构信息

Department of Neurology, University of California Davis.

出版信息

Radiology. 1988 Sep;168(3):823-5. doi: 10.1148/radiology.168.3.3136509.

DOI:10.1148/radiology.168.3.3136509

PMID:3136509

Abstract

Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.

摘要

在兔头部进行了反映醛糖还原酶-山梨醇（ARS）途径中葡萄糖代谢的无创性代谢磁共振（MR）成像；给予氟化葡萄糖类似物3-氟-3-脱氧-D-葡萄糖（3FD-葡萄糖）后，生成了氟-19图像。3FD-葡萄糖图像显示脂肪组织对3FD-葡萄糖有显著摄取，表明其在葡萄糖负荷过量时的缓冲作用。3-氟-3-脱氧-D-山梨醇（3FD-山梨醇）图像显示了醛糖还原酶活性的空间分布以及晶状体中山梨醇的显著积累。3-氟-3-脱氧-D-果糖（3FD-果糖）图像显示肌肉组织对果糖有优先摄取。3FD-葡萄糖的极低毒性表明其在代谢成像临床应用方面具有前景。