Nakada T, Kwee I L, Card P J, Matwiyoff N A, Griffey B V, Griffey R H
Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553.
Magn Reson Med. 1988 Mar;6(3):307-13. doi: 10.1002/mrm.1910060309.
Metabolic imaging reflecting glucose metabolism in the glycolytic and aldose reductase sorbitol (ARS) pathways was performed noninvasively in rat using fluorinated glucose analogs, 2-fluoro-2-deoxy-D-glucose (2-FDG) or 3-fluoro-3-deoxy-D-glucose (3-FDG), and fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging. 19F images of 2-FDG-6-phosphate, a main metabolite of 2-FDG in the glycolytic pathway, showed high glucose utilization in the brain, spinal cord, and heart. Images of 3-fluoro-3-deoxy-D-sorbitol (3-FDSL), a main metabolite of 3-FDG in the ARS pathway, demonstrated the heterogeneous nature of the spatial distribution of aldose reductase activities, being highest in the brain and lens. The extremely low toxicity of 3-FDG indicates promise for clinical application of 3-FDG NMR imaging.
利用氟化葡萄糖类似物2-氟-2-脱氧-D-葡萄糖（2-FDG）或3-氟-3-脱氧-D-葡萄糖（3-FDG）以及氟-19（19F）核磁共振（NMR）成像技术，在大鼠体内对糖酵解途径和醛糖还原酶山梨醇（ARS）途径中的葡萄糖代谢进行了非侵入性代谢成像。糖酵解途径中2-FDG的主要代谢产物2-FDG-6-磷酸的19F图像显示，大脑、脊髓和心脏中的葡萄糖利用率很高。ARS途径中3-FDG的主要代谢产物3-氟-3-脱氧-D-山梨醇（3-FDSL）的图像显示了醛糖还原酶活性空间分布的异质性，在大脑和晶状体中最高。3-FDG的极低毒性表明其在3-FDG NMR成像临床应用方面具有前景。
