Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Shenzhen University School of Medicine, Shenzhen, China.
FEBS Lett. 2020 Jan;594(1):153-160. doi: 10.1002/1873-3468.13560. Epub 2019 Aug 9.
Bromhexine was reported to relieve the symptoms of Sjogren Syndrome at an early stage. However, the underlying mechanism remains unclear. Here, we administered bromhexine at low doses in human primary conjunctival fornix epithelial cells, and found it stimulated MUC5AC secretion and lipid droplet production. Expression of the metabolism-related gene CHML was also upregulated by bromhexine treatment, and REP2, the protein produced by the CHML gene, was induced. These results suggest that bromhexine is a potential candidate eye drop drug for the treatment of multiple types of dry eye disease, not only limited to the treatment of dry eyes in Sjogren Syndrome.
溴己新被报道可在早期缓解干燥综合征的症状。然而，其潜在机制尚不清楚。在这里，我们在人原发性结膜穹窿上皮细胞中给予低剂量的溴己新，发现其可刺激 MUC5AC 分泌和脂滴生成。溴己新处理还上调了与代谢相关的 CHML 基因的表达，并且诱导了由 CHML 基因产生的 REP2 蛋白。这些结果表明，溴己新是一种有潜力的眼药水药物候选物，可用于治疗多种类型的干眼症，不仅限于干燥综合征引起的干眼症的治疗。
