空气中磺酰基-1,2,3-三唑的高度区域选择性自由基转化
Highly Regioselective Radical Transformation of -Sulfonyl-1,2,3-triazoles in Air.
作者信息
Li Zi, Wei Qinghua, Song Longlong, Han Wangyujing, Wu Xiang, Zhao Yun, Xia Fei, Liu Shunying
机构信息
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering , East China Normal University , 3663 North Zhongshan Road , Shanghai 200062 , P. R. China.
出版信息
Org Lett. 2019 Aug 16;21(16):6413-6417. doi: 10.1021/acs.orglett.9b02269. Epub 2019 Jul 31.
The classic transformations of -sulfonyl-1,2,3-triazoles were processed via nitrogen anion (hydrolysis, etc.) and carbene intermediates, and no efficient examples via radical intermediates were developed. Here, we reported a catalyst-free radical chain transformation of -sulfonyl-1,2,3-triazoles to access an intermolecular oxidative C(sp)-H coupling to yield -selective products in air without any catalysts.
-磺酰基-1,2,3-三唑的经典转化是通过氮阴离子（水解等）和卡宾中间体进行的，尚未开发出通过自由基中间体的有效实例。在此，我们报道了一种无催化剂的-磺酰基-1,2,3-三唑自由基链转化反应，该反应能够在空气中实现分子间氧化C(sp)-H偶联，无需任何催化剂即可生成-选择性产物。
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