Sahebari Maryam, Rezaieyazdi Zahra, Hashemy Seyed Isaac, Khorasani Sahar, Shahgordi Sanaz, Alizadeh Mohammad Karim, Ghaeni Abdolmomen, Khodashahi Mandana
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Eur J Rheumatol. 2018 Dec 19;6(2):76-80. doi: 10.5152/eurjrheum.2018.18114. Print 2019 Apr.
The present study aimed to determine the relationship between the serum hepcidin level and disease activity in patients with rheumatoid arthritis (RA).
This study was conducted on 80 patients with RA (36 cases with anemia of chronic disease [ACD] and 44 patients without ACD). Disease activity was measured by the 28-joint Disease Activity Score based on the erythrocyte sedimentation rate (DAS28-ESR). According to the DAS28-ESR score, 52 and 28 cases were categorized as inactive to moderately active RA (DAS28-ESR≤5.1) and highly active RA (DAS28-ESR>5.1), respectively. In addition, the serum hepcidin level was evaluated in all patients to determine its correlation with the DAS28-ESR score.
There was no significant difference between the RA with ACD and RA without ACD groups in terms of the median (interquartile range) hepcidin level (1207 [985.2] vs. 923.8 [677.3] ng/mL; P=0.57). Likewise, no significant difference was observed between the active RA and inactive to moderately active RA groups in this regard (1131.8 [991.3] vs. 1090.9 [631.4] ng/mL; P=0.53).
Hepcidin has no association with disease activity in RA. Therefore, it is not necessary to measure hepcidin to determine the RA activity.
本研究旨在确定类风湿关节炎（RA）患者血清铁调素水平与疾病活动度之间的关系。
本研究对80例RA患者进行（36例患有慢性病贫血[ACD]，44例无ACD）。疾病活动度通过基于红细胞沉降率的28关节疾病活动评分（DAS28-ESR）来衡量。根据DAS28-ESR评分，52例和28例分别被归类为非活动性至中度活动性RA（DAS28-ESR≤5.1）和高度活动性RA（DAS28-ESR>5.1）。此外，对所有患者的血清铁调素水平进行评估，以确定其与DAS28-ESR评分的相关性。
在铁调素水平中位数（四分位间距）方面，患有ACD的RA组和未患有ACD的RA组之间无显著差异（1207[985.2]对923.8[677.3]ng/mL；P=0.57）。同样，在这方面，活动性RA组与非活动性至中度活动性RA组之间未观察到显著差异（1131.8[991.3]对1090.9[631.4]ng/mL；P=0.53）。
铁调素与RA的疾病活动度无关。因此，没有必要通过检测铁调素水平来确定RA的活动度。
