Department of Ophthalmology, University of California San Francisco, San Francisco, California, U.S.A.
Ophthalmic Plast Reconstr Surg. 2019 Sep/Oct;35(5):e118-e121. doi: 10.1097/IOP.0000000000001447.
Ductal carcinoma of the lacrimal gland is a very rare and aggressive neoplasm, with clinical and histopathologic similarities to salivary ductal carcinoma. Of the 25 previously reported cases, 2 patients had metastases to local lymph nodes confirmed on pathologic examination. The authors now report the clinical presentation, histopathologic and immunohistochemical features, and the treatment of a third patient with lacrimal gland ductal carcinoma with spread to local lymph nodes. In contrast to ductal carcinoma, lymph node involvement has not been reported in the largest series of adenoid cystic carcinoma, a much more common lacrimal gland malignancy. This case highlights the need for possible lymph node surveillance in patients with lacrimal gland ductal carcinoma.
泪腺导管癌是一种非常罕见且侵袭性的肿瘤，其临床表现和组织病理学特征与唾液腺导管癌相似。在之前报道的 25 例病例中，有 2 例患者的局部淋巴结转移经病理检查证实。作者现在报告第三例泪腺癌导管癌伴局部淋巴结转移的临床表现、组织病理学和免疫组织化学特征及治疗。与导管癌不同，在最大系列的腺样囊性癌（一种更为常见的泪腺恶性肿瘤）中，并未报道淋巴结受累。本病例提示在泪腺癌导管癌患者中可能需要进行淋巴结监测。
