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两例皮肤局限性黏蛋白沉积症的临床、皮肤镜及组织学特征

Clinical, dermoscopic, and histologic aspects of two cases of cutaneous focal mucinosis.

作者信息

Biondo Giovanni, Sola Simona, Pastorino Carlotta, Massone Cesare

机构信息

Department of Dermatology, P. Giaccone Hospital, University of Palermo, Palermo, Italy.

Surgical Pathology Unit, Galliera Hospital, Genova, Italy.

出版信息

An Bras Dermatol. 2019 Jul 29;94(3):334-336. doi: 10.1590/abd1806-4841.20198381.

DOI:10.1590/abd1806-4841.20198381
PMID:31365664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6668945/
Abstract

Cutaneous mucinoses are a complex and diverse group of connective tissue disorders characterized by the accumulation of mucin and/or glycosaminoglycan in the skin and adnexa. Cutaneous focal mucinosis appears as a solitary, asymptomatic, skin-colored to white papule, nodule, or plaque located anywhere on the body or in the oral cavity. It presents mainly in adults and is characterized on histopathology by mucin throughout the upper and mid dermis. We describe the dermoscopy of two cases of cutaneous focal mucinosis. Both lesions presented a nonspecific homogenous whitish pattern; the first case also exhibited a sharply demarcated yellow border.

摘要

皮肤黏蛋白沉积症是一组复杂多样的结缔组织疾病,其特征是皮肤和附属器中黏蛋白和/或糖胺聚糖的蓄积。皮肤局限性黏蛋白沉积症表现为单个、无症状、肤色至白色的丘疹、结节或斑块,位于身体任何部位或口腔内。它主要发生于成年人,组织病理学特征为整个真皮上层和中层有黏蛋白。我们描述了两例皮肤局限性黏蛋白沉积症的皮肤镜检查情况。两个皮损均呈现非特异性均匀白色模式;第一例还表现出边界清晰的黄色边缘。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/c2a3e410e266/abd-94-03-0334-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/662787f661ca/abd-94-03-0334-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/8b109519e6ce/abd-94-03-0334-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/a3fc0e192d6a/abd-94-03-0334-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/a3e5ba5672ee/abd-94-03-0334-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/fd17631623ce/abd-94-03-0334-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/c2a3e410e266/abd-94-03-0334-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/662787f661ca/abd-94-03-0334-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/8b109519e6ce/abd-94-03-0334-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/a3fc0e192d6a/abd-94-03-0334-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/a3e5ba5672ee/abd-94-03-0334-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/fd17631623ce/abd-94-03-0334-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bac/6668945/c2a3e410e266/abd-94-03-0334-g06.jpg

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本文引用的文献

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Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions.孤立性皮肤局灶性黏蛋白沉积症:11例软纤维瘤样皮肤黏液性病变的临床病理研究
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Cutaneous focal mucinosis associated with reticular erythematous mucinosis and scleromyxedema.与网状红斑性黏蛋白病和硬化性黏液水肿相关的皮肤局限性黏蛋白病
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