Mello Renan Bernardes de, Vale Everton Carlos Siviero do
Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
An Bras Dermatol. 2019 Jul 29;94(3):337-340. doi: 10.1590/abd1806-4841.20198500.
Necrobiotic xanthogranuloma is a rare chronic condition, belonging to the group C non-Langerhans cell histiocytoses, which is relevant due to the possibility of extracutaneous involvement and association with systemic diseases, particularly hematologic malignancies. The case reported here was only diagnosed after nine years of evolution and was associated with plasma cell dyscrasia. After treatment with cyclophosphamide, dexamethasone, and thalidomide, there was a reduction of cutaneous lesions and serum levels of monoclonal protein.
坏死性黄色肉芽肿是一种罕见的慢性疾病，属于C组非朗格汉斯细胞组织细胞增多症，因其可能累及皮肤外以及与全身性疾病尤其是血液系统恶性肿瘤相关而受到关注。此处报告的病例在病程九年之后才得以确诊，且与浆细胞异常增生有关。经环磷酰胺、地塞米松和沙利度胺治疗后，皮肤损害及单克隆蛋白的血清水平有所降低。
