Egghart G, Steegmüller O, Wenderoth U, Hautmann R
Urologische Universitätsklinik und Poliklinik Ulm.
Urologe A. 1988 May;27(3):147-51.
Several studies indicate that intravesical chemotherapy is an effective treatment for superficial bladder tumors. We have carried out a retrospective study of 321 patients with superficial bladder cancer who where treated between 1972 and 1982 at our Institute. In 63 of the 321 patients, adriamycin 50 mg or mitomycin C 20 mg was administered topically. In an average follow-up of 20.2 months the overall recurrence rate was 54.2%. In the control group the mean times to recurrence were 21 months for Ta tumors and 17.4 months for T1 tumors, while those in the topically treated patients were 14 and 8 months for the mitomycin and 17 and 6 months for the adriamycin group. The only factor that influenced the recurrence rate was the depth of infiltration of the lamina propria. Our data indicate that topical chemotherapy has no effect in patients with superficial cancer of the bladder.
多项研究表明，膀胱内化疗是治疗浅表性膀胱肿瘤的一种有效方法。我们对1972年至1982年间在我院接受治疗的321例浅表性膀胱癌患者进行了一项回顾性研究。在321例患者中的63例中，局部给予阿霉素50毫克或丝裂霉素C 20毫克。平均随访20.2个月，总复发率为54.2%。在对照组中，Ta肿瘤的平均复发时间为21个月，T1肿瘤为17.4个月，而局部治疗患者中，丝裂霉素组为14个月和8个月，阿霉素组为17个月和6个月。唯一影响复发率的因素是固有层的浸润深度。我们的数据表明，局部化疗对浅表性膀胱癌患者无效。
