J Phys Act Health. 2019 Oct 1;16(10):830-835. doi: 10.1123/jpah.2018-0609. Epub 2019 Jul 30.
Metabolic syndrome (MetS) is a combination of risk factors for cardiovascular disease and type 2 diabetes mellitus. The prevalence of MetS worldwide is increasing. There is no study investigating the economic burden of MetS, especially in developing countries, on medication-related expenditure. The aim of this study was to investigate the association of medication-related expenditures with MetS and to explore how physical activity (PA) may influence this association.
A total of 620 participants, 50 years or older, randomly selected in the city of Bauru, Brazil. Participants were followed from 2010 to 2014, and data on health care expenditure were collected annually. PA questionnaire was applied at baseline, 2 (2012), and 4 (2014) years later.
Mean age was 64.7 (95% confidence interval, 64.1-65.3). MetS was associated with higher medication expenditure related to diseases of the circulatory (P <.01) and endocrine (P <.01) systems. MetS explained 17.2% of medication-related expenditures, whereas PA slightly attenuated this association, explaining 1.1% of all health care costs.
This study demonstrates that MetS has a significant burden on health care expenditures among adults, whereas PA seems to affect this phenomenon significantly, but in low magnitude.
代谢综合征（MetS）是心血管疾病和 2 型糖尿病风险因素的组合。全球代谢综合征的患病率正在增加。目前还没有研究调查代谢综合征对药物相关支出的经济负担，特别是在发展中国家。本研究旨在调查药物相关支出与代谢综合征的相关性，并探讨体力活动（PA）如何影响这种相关性。
本研究共纳入 620 名年龄在 50 岁或以上的参与者，他们是在巴西包鲁市随机选择的。参与者从 2010 年到 2014 年进行随访，每年收集医疗支出数据。在基线、2 年（2012 年）和 4 年（2014 年）后应用体力活动问卷。
平均年龄为 64.7（95%置信区间，64.1-65.3）。代谢综合征与循环系统（P<.01）和内分泌系统（P<.01）疾病的药物支出较高相关。代谢综合征解释了 17.2%的药物相关支出，而体力活动略微减弱了这种关联，解释了所有医疗保健费用的 1.1%。
本研究表明，代谢综合征对成年人的医疗保健支出有重大负担，而体力活动似乎对这种现象有显著影响，但影响幅度较小。
