Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Int J Mol Sci. 2019 Jul 30;20(15):3726. doi: 10.3390/ijms20153726.
Cardiovascular disease remains the leading global cause of death, and the number of patients with coronary artery disease (CAD) and exhausted therapeutic options (i.e., percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical treatment) is on the rise. Therefore, the evaluation of new therapeutic approaches to offer an alternative treatment strategy for these patients is necessary. A promising research field is the promotion of the coronary collateral circulation, an arterio-arterial network able to prevent or reduce myocardial ischemia in CAD. This review summarizes the basic principles of the human coronary collateral circulation, its extracardiac anastomoses as well as the different therapeutic approaches, especially that of stimulating the extracardiac collateral circulation via permanent occlusion of the internal mammary arteries.
心血管疾病仍然是全球主要的死亡原因，患有冠状动脉疾病 (CAD) 和治疗选择有限的患者人数（即经皮冠状动脉介入治疗 (PCI)、冠状动脉旁路移植术 (CABG) 和药物治疗）正在增加。因此，有必要评估新的治疗方法，为这些患者提供替代治疗策略。一个有前途的研究领域是促进冠状动脉侧支循环，即能够预防或减少 CAD 中心肌缺血的动脉到动脉网络。这篇综述总结了人类冠状动脉侧支循环的基本原理、其心外吻合以及不同的治疗方法，特别是通过永久性闭塞内乳动脉来刺激心外侧支循环的方法。
