Thomas H C
Department of Medicine, St. Mary's Hospital Medical School, University of London, United Kingdom.
Am J Med. 1988 Aug 29;85(2A):135-40.
Although the strategy of replication of hepatitis B virus has now been described, the majority of the compounds that have activity against the virus have been identified by empirical means. Vidarabine, acyclovir, and interferons alpha and beta are capable of inhibiting hepatitis B virus replication; however, at the present time, optimal treatment regimens have not been defined. The effects of interferons alpha and beta given in short courses are only transient. Longer courses of intermittent therapy have resulted in seroconversion rates of up to 50 percent in Western European carriers. It is becoming apparent that patients infected with hepatitis B virus in adult life have a relative deficiency of interferon alpha, and it is these patients who have the best responses to protracted courses of intermittent therapy.
虽然现在已经描述了乙型肝炎病毒的复制策略，但大多数对该病毒有活性的化合物是通过经验方法鉴定出来的。阿糖腺苷、阿昔洛韦以及α干扰素和β干扰素能够抑制乙型肝炎病毒复制；然而，目前尚未确定最佳治疗方案。短疗程给予α干扰素和β干扰素的效果只是暂时的。在西欧携带者中，较长疗程的间歇治疗已使血清转换率高达50%。越来越明显的是，成年期感染乙型肝炎病毒的患者存在α干扰素相对缺乏的情况，而正是这些患者对长期间歇治疗疗程反应最佳。
