人类肿瘤发生学：年龄和性别扮演的角色。
Human Carcinogenesis: The Role of Age and Gender.
机构信息
Department of Health Science and Nursing, University of Hartford, West Hartford, CT, U.S.A.
出版信息
Anticancer Res. 2019 Aug;39(8):4385-4391. doi: 10.21873/anticanres.13608.
BACKGROUND/AIM: To identify the reason for age and gender differences in cancer risk.
PATIENTS AND METHODS
Age-standardized incidence rates for 17 cancer types were compared between genders in 50 populations. For each cancer type, the female/male rate ratio was listed in fixed order of population. Correlation coefficients were calculated between these lists in all pairwise combinations. For each population, the female/male rate ratio was listed in fixed order of cancer. Correlation coefficients were calculated between lists in all pairwise combinations.
RESULTS
Only four pairwise combinations for cancer type gave a correlation coefficient greater than 0.700. For each population, the lowest correlation coefficient was 0.950.
CONCLUSION
The reason for the differences in risk of cancer varies with each type of cancer, but remains fixed in all populations. It is suspected that species-specific genes control stem cell telomere dynamics in a fixed strategy at rates that vary among tissues and between genders.
背景/目的：确定癌症风险在年龄和性别方面存在差异的原因。
患者和方法
比较了 50 个人群中 17 种癌症类型在性别之间的年龄标准化发病率。对于每种癌症类型，按人口固定顺序列出女性/男性比率。计算了所有两两组合中这些列表之间的相关系数。对于每个人群，按癌症的固定顺序列出女性/男性比率。计算了所有两两组合中列表之间的相关系数。
结果
只有四种癌症类型的两两组合给出的相关系数大于 0.700。对于每个人群，最低的相关系数为 0.950。
结论
癌症风险差异的原因因每种癌症类型而异，但在所有人群中保持不变。据推测，物种特异性基因以固定策略控制干细胞端粒动力学，其速率在组织之间和性别之间存在差异。
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