NADPH 氧化酶 5 在人结肠癌中的临床意义。
Clinical Significance of NADPH Oxidase 5 in Human Colon Cancer.
机构信息
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
出版信息
Anticancer Res. 2019 Aug;39(8):4405-4410. doi: 10.21873/anticanres.13611.
BACKGROUND/AIM: Recent studies have reported the involvement of NADPH oxidases (NOXs) in tumor progression. However, the role of NOX5 in colon cancer is unclear. We examined the clinical significance of NOX5 expression in colon cancer.
PATIENTS AND METHODS
NOX5 expression was evaluated by immunohistochemistry in 119 patients with stage II or III colon cancer, and the relationship between NOX5 expression and clinicopathological data was analyzed.
RESULTS
Of all tissues, 39.5% were negative and 60.5% were positive for NOX5 expression. Positive expression was significantly associated with undifferentiated histology (p=0.037) and lymph node metastasis (p=0.023). The 5-year progression-free survival rate of NOX5-positive patients was significantly worse than that of NOX5-negative patients (p=0.046). The rates of local recurrence observed in NOX5-positive patients were higher than that in NOX5-negative patients.
CONCLUSION
NOX5 expression may be related to poor prognostic factors and could be useful as a prognostic biomarker.
背景/目的：最近的研究报告 NADPH 氧化酶（NOXs）参与肿瘤进展。然而，NOX5 在结肠癌中的作用尚不清楚。我们研究了 NOX5 表达在结肠癌中的临床意义。
患者和方法
通过免疫组织化学方法评估了 119 例 II 期或 III 期结肠癌患者的 NOX5 表达，并分析了 NOX5 表达与临床病理数据之间的关系。
结果
所有组织中，NOX5 表达阴性的占 39.5%，阳性的占 60.5%。阳性表达与未分化组织学（p=0.037）和淋巴结转移（p=0.023）显著相关。NOX5 阳性患者的 5 年无进展生存率明显低于 NOX5 阴性患者（p=0.046）。NOX5 阳性患者的局部复发率高于 NOX5 阴性患者。
结论
NOX5 表达可能与不良预后因素有关，可作为预后标志物。
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