Mycinski C, Fauchier J P, Cosnay P, Chantepie A, Marchand M, Moquet B, Huguet R G, Guillou L
Service de cardiologie B, hôpital Trousseau, Tours.
Arch Mal Coeur Vaiss. 1988 May;81(5):685-92.
An electrophysiological study was carried out pre- and postoperatively in 25 patients (children and adults) presenting with an atrial septal defect of the ostium secundum type (OSASD). The purposes of the study were to find out whether early electrophysiological abnormalities were present in children, to compare the results obtained in children and in adults and to evaluate the impact of surgery by comparing preoperative and late postoperative electrophysiological data. Patients were divided into two groups. Group I was composed of 11 children (mean age 8.18 +/- 1.03 years) with a mean pulmonary/systemic blood flow ratio of 2.33 +/- 0.24. Group II comprised 14 adults (mean age 36.79 +/- 4.89 years) with a mean pulmonary/systemic blood flow ratio of 3.42 +/- 0.24. Preoperatively, in group I 55 p. 100 of the patients (6/11) had sinus node dysfunction, 18 p. 100 (2/11) had disturbances of atrioventricular conduction, and none had atrial dysrhythmia. Preoperatively, in group II 43 p. 100 of the patients (6/14) had sinus node dysfunction, 36 p. 100 (5/14) had disturbances of atrioventricular conduction, and 36 p. 100 (5/14) had sustained atrial dysrhythmia (flutter or paroxysmal atrial fibrillation). The frequency of sustained atrial dysrhythmia correlated positively with the patient's age and with the presence of sinus node dysfunction. Following surgical closure of the atrial septal defect, the electrophysiological parameters were not significantly modified in both groups. This study confirmed the presence of early electrophysiological abnormalities of sinus node function and atrioventricular conduction in children with OSASD. The most significant finding in adults was the occurrence of atrial dysrhythmias in the oldest patients.(ABSTRACT TRUNCATED AT 250 WORDS)
对25例继发孔型房间隔缺损(OSASD)患者(包括儿童和成人)进行了术前和术后的电生理研究。该研究的目的是查明儿童是否存在早期电生理异常,比较儿童和成人的研究结果,并通过比较术前和术后晚期的电生理数据来评估手术的影响。患者分为两组。第一组由11名儿童组成(平均年龄8.18±1.03岁),平均肺/体血流比为2.33±0.24。第二组包括14名成人(平均年龄36.79±4.89岁),平均肺/体血流比为3.42±0.24。术前,第一组中55%(6/11)的患者有窦房结功能障碍,18%(2/11)有房室传导障碍,无房性心律失常。术前,第二组中43%(6/14)的患者有窦房结功能障碍,36%(5/14)有房室传导障碍,36%(5/14)有持续性房性心律失常(扑动或阵发性心房颤动)。持续性房性心律失常的发生率与患者年龄和窦房结功能障碍的存在呈正相关。房间隔缺损手术闭合后,两组的电生理参数均无明显改变。本研究证实了OSASD儿童存在窦房结功能和房室传导的早期电生理异常。成人中最显著的发现是年龄最大的患者出现房性心律失常。(摘要截断于250字)