Zhang Zhen-Zhen, Wang Ping, Kong Xiang-Lei, Mao Wen-Li, Cui Mei-Yu
Taishan Medical University, Tai'an, Shandong 271000, China.
Department of Nephrology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, China.
Chronic Dis Transl Med. 2018 Jul 13;5(2):122-128. doi: 10.1016/j.cdtm.2018.06.001. eCollection 2019 Jun.
Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity (PWV) is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations. Accordingly, we conducted a cross-sectional study to explore the association of Hb with PWV.
A total of 6642 adults aged 54.5 ± 11.2 years undergoing physical examinations were enrolled, 71.7% of whom were males. Arterial stiffness was evaluated by carotid-femoral PWV (cfPWV). Multivariable regression analyses were performed to determine the relationship between Hb and increased cfPWV.
In this study, the mean Hb (per 10 g/L increase) was 144.7 ± 13.9 g/L, and the mean cfPWV was 15.1 ± 3.1 m/s. cfPWV was significantly higher in high hemoglobin groups ≥15.4 g/L (Quartile 4) than in the lowest hemoglobin group (Quartile 1 ≤ 13.6 g/L; < 0.001). Multiple linear regression analysis revealed that Hb positively correlated with cfPWV ( = 0.16, < 0.01). Univariate Logistic regression analysis revealed that Hb was associated with increased cfPWV, with an odd ratio () of 1.46 (95% confidence interval [], 1.39-1.54). After adjusting for potential confounders, Hb and the highest Hb quartile group were also independently associated with increased cfPWV, with a fully adjusted of 1.11 (95% , 1.02-1.20) and 1.45 (95% , 1.01-2.08), respectively.
This study demonstrated that Hb levels significantly correlate with increased cfPWV.
已知血红蛋白（Hb）水平升高与心血管事件和死亡率增加有关。因此，我们推测高Hb水平与动脉僵硬度有关。脉搏波速度（PWV）是一种用于测量动脉僵硬度的简单无创方法，通常用于评估普通人群的心血管疾病。据此，我们进行了一项横断面研究，以探讨Hb与PWV之间的关联。
共纳入6642名年龄在54.5±11.2岁接受体检的成年人，其中71.7%为男性。通过颈股动脉PWV（cfPWV）评估动脉僵硬度。进行多变量回归分析以确定Hb与cfPWV升高之间的关系。
在本研究中，平均Hb（每增加10 g/L）为144.7±13.9 g/L，平均cfPWV为15.1±3.1 m/s。血红蛋白水平≥15.4 g/L（四分位数4）的高血红蛋白组的cfPWV显著高于最低血红蛋白组（四分位数1≤13.6 g/L；P<0.001）。多元线性回归分析显示，Hb与cfPWV呈正相关（β=0.16，P<0.01）。单因素Logistic回归分析显示，Hb与cfPWV升高有关，比值比（OR）为1.46（95%置信区间[CI]，1.39 - 1.54）。在调整潜在混杂因素后，Hb和最高Hb四分位数组也与cfPWV升高独立相关，完全调整后的OR分别为1.11（95%CI，1.02 - 1.20）和1.45（95%CI，1.01 - 2.08）。
本研究表明，Hb水平与cfPWV升高显著相关。
