Hartzen S H, Frimodt-Möller N, Andreasen J J
Department of Antibiotics, Statens Seruminstitut, Copenhagen, Denmark.
APMIS. 1988 Jul;96(7):584-8.
The in vitro antibacterial activities of penicillin, ampicillin, piperacillin, azlocillin, vancomycin, erythromycin, clindamycin, gentamicin, streptomycin, cefotaxime, and ceftriaxone against 198 S. faecalis strains were investigated, employing an agar dilution technique. Results were generally in accord with those of other studies. Ampicillin and penicillin showed equal activities. Twenty percent of the strains were resistant to erythromycin, which correlated with resistance to clindamycin. The activity of cefotaxime was fairly good, but the clinical importance of this observation warrants further investigation. Twenty percent showed high-level resistance to streptomycin. High-grade resistance to gentamicin was noted for one isolate only, making gentamicin the first-choice aminoglycoside for combination treatment at present.
采用琼脂稀释技术，研究了青霉素、氨苄西林、哌拉西林、阿洛西林、万古霉素、红霉素、克林霉素、庆大霉素、链霉素、头孢噻肟和头孢曲松对198株粪肠球菌的体外抗菌活性。结果总体上与其他研究一致。氨苄西林和青霉素表现出同等活性。20%的菌株对红霉素耐药，这与对克林霉素的耐药相关。头孢噻肟的活性相当好，但这一观察结果的临床重要性值得进一步研究。20%的菌株对链霉素表现出高水平耐药。仅1株分离菌对庆大霉素表现出高度耐药，这使得庆大霉素成为目前联合治疗的首选氨基糖苷类药物。
