Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Sport Health and Science, School of Physical Education and Sports, Marmara University, Istanbul, Turkey.
Pituitary. 2019 Oct;22(5):497-506. doi: 10.1007/s11102-019-00979-3.
Patients with acromegaly may have balance abnormalities due to changes in body composition. We aim to compare static and dynamic balances in patients with acromegaly and healthy volunteers, and to evaluate the effects of exercise on balance in patients with acromegaly.
This prospective study included 25 patients with acromegaly followed at endocrinology clinic of Cerrahpasa Medical Faculty and 13 healthy volunteers. The acromegalic patients were divided into 2 groups. Group A (n = 11) attended an exercise program 3 days/week for 3 months, whereas group B (n = 14) and healthy volunteers (Group C) were exercise-free. Bipedal and unipedal stance static and dynamic balance tests were performed using a Prokin 252N device.
The ages, demographic characteristics, and body compositions were similar. In acromegalic patients, the static balance parameters of displacement of center-of-pressure in anterior-posterior direction (C.o.P.Y) while eyes open (p = 0.002) and on left leg (p = 0.001), in left-right direction (C.o.P.X) on right leg (p = 0.03), eyes-closed average medio-lateral velocity (AMLV) (p = 0.001) and the dynamic parameter of forward/backward front/right standard deviation (FBFRSD) (p = 0.02) were significantly different from healthy controls. When the exercise effect on balance was evaluated between group A and B, there were significant improvements in most parameters of dynamic balance measurements of both forward-backward and medial-lateral sway (FBFRSD, FBDME, and RLBLSD) (p = 0.02, p = 0.02, and p = 0.004, respectively) after exercise in group A.
Patients with acromegaly had impairments at various static and dynamic balance parameters, especially in posterior direction. After a 3-month exercise program, the dynamic balance profoundly improved, but static balance was relatively preserved in patients with acromegaly.
肢端肥大症患者由于身体成分的变化可能会出现平衡异常。我们旨在比较肢端肥大症患者与健康志愿者的静态和动态平衡，并评估运动对肢端肥大症患者平衡的影响。
这项前瞻性研究纳入了在切拉哈帕斯医科大学内分泌科就诊的 25 例肢端肥大症患者和 13 名健康志愿者。肢端肥大症患者分为 2 组。A 组（n=11）参加了为期 3 个月、每周 3 天的运动方案，而 B 组（n=14）和健康志愿者（C 组）不进行运动。使用 Prokin 252N 设备进行双足和单足静态和动态平衡测试。
年龄、人口统计学特征和身体成分相似。在肢端肥大症患者中，睁眼时（p=0.002）和左腿时（p=0.001）前后方向（C.o.P.Y）、右腿时（p=0.03）左右方向（C.o.P.X）的压力中心位移静态平衡参数，闭眼时平均左右向速度（AMLV）（p=0.001）以及前后/左右标准偏差（FBFRSD）（p=0.02）等动态平衡参数与健康对照组存在显著差异。当评估 A 组和 B 组之间运动对平衡的影响时，A 组在前后和左右摆动的大多数动态平衡测量参数（FBFRSD、FBDME 和 RLBLSD）方面均有显著改善（p=0.02、p=0.02 和 p=0.004）。
肢端肥大症患者在各种静态和动态平衡参数方面存在障碍，尤其是在后向。经过 3 个月的运动方案后，动态平衡明显改善，但肢端肥大症患者的静态平衡相对保留。
