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肢端肥大症中的身体成分、肌肉减少症和血清肌动蛋白：一篇叙述性综述。

Body Composition, Sarcopenia, and Serum Myokines in Acromegaly: A Narrative Review.

作者信息

Inojosa Arthur Costa, Ribeiro Ana Vitória Hirt, Araújo Thaís Florêncio, Xavier Maria Eduarda, Rêgo Daniella, Bandeira Francisco

机构信息

Division of Endocrinology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil.

FBandeira Endocrine Institute, Recife, Brazil.

出版信息

J Bone Metab. 2024 Aug;31(3):182-195. doi: 10.11005/jbm.2024.31.3.182. Epub 2024 Aug 31.

DOI:10.11005/jbm.2024.31.3.182
PMID:39307519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11416875/
Abstract

Patients with active acromegaly have a higher percentage of lean body mass, a lower percentage of fat body mass, and an increase in their extracellular water compartment compared to healthy individuals. However, muscle function appears to be compromised in patients with acromegaly, with some experiencing worsened physical performance and sarcopenia. Myokine alterations, insulin resistance, dysregulation of protein metabolism, muscle oxidative stress, neuromuscular junction impairment, and increased ectopic intramuscular fat deposits may play roles in muscle dysfunction in patients with acromegaly.

摘要

与健康个体相比，患有活动性肢端肥大症的患者瘦体重百分比更高，脂肪体重百分比更低，细胞外液腔增加。然而，肢端肥大症患者的肌肉功能似乎受到损害，一些患者身体机能恶化并出现肌肉减少症。肌动蛋白改变、胰岛素抵抗、蛋白质代谢失调、肌肉氧化应激、神经肌肉接头损伤以及肌内异位脂肪沉积增加可能在肢端肥大症患者的肌肉功能障碍中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/0109ac533512/jbm-2024-31-3-182f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/54ad09da0060/jbm-2024-31-3-182f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/70f7a7c27f02/jbm-2024-31-3-182f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/0109ac533512/jbm-2024-31-3-182f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/54ad09da0060/jbm-2024-31-3-182f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/70f7a7c27f02/jbm-2024-31-3-182f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9a9/11416875/0109ac533512/jbm-2024-31-3-182f3.jpg

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