Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, No. 8 Dianli Road,, ZhenJiang, 212002, China.
Biol Trace Elem Res. 2020 May;195(1):55-62. doi: 10.1007/s12011-019-01847-8. Epub 2019 Jul 31.
The association of circulating selenium level with mortality remains controversial. This meta-analysis investigated the association between elevated circulating selenium level and cardiovascular or all-cause mortality in the general population. PubMed and Embase databases (up to January 20, 2019) were searched for observational studies or post hoc analyses of randomized controlled trials that evaluated the association between elevated circulating selenium level and cardiovascular or all-cause mortality in the general population. Twelve observational studies (ten cohort and two case-control studies) with a total of 25,667 individuals were included. Comparison with the lowest and the highest circulating selenium level showed that the pooled risk ratio (RR) values of all-cause mortality and cardiovascular mortality were 1.36 (95% confidence intervals [CI] 1.18-1.58) and 1.35 (95% CI 1.13-1.62), respectively. When analyzed selenium level as a continuous variable, each standard deviation selenium increase significantly reduced 20% all-cause mortality risk. However, the lowest circulating selenium level was not associated with a high risk of coronary mortality (RR 1.43; 95% CI 0.93-2.19). This meta-analysis indicated that low circulating selenium level was associated with higher risk of cardiovascular or all-cause mortality in the general population. Low circulating selenium level did not confer significant effect on coronary death.
循环硒水平与死亡率之间的关联仍存在争议。本荟萃分析调查了循环硒水平升高与一般人群中心血管或全因死亡率之间的关联。检索了 PubMed 和 Embase 数据库（截至 2019 年 1 月 20 日），以寻找评估循环硒水平升高与一般人群中心血管或全因死亡率之间关联的观察性研究或随机对照试验的事后分析。共纳入 12 项观察性研究（10 项队列研究和 2 项病例对照研究），共 25667 人。与最低和最高循环硒水平进行比较后发现，全因死亡率和心血管死亡率的合并风险比（RR）值分别为 1.36（95%置信区间[CI] 1.18-1.58）和 1.35（95% CI 1.13-1.62）。当分析硒水平作为连续变量时，每个标准偏差硒的增加可显著降低 20%的全因死亡率风险。然而，最低循环硒水平与冠心病死亡率升高无关（RR 1.43；95% CI 0.93-2.19）。本荟萃分析表明，循环硒水平低与一般人群中心血管或全因死亡率风险增加相关。低循环硒水平对冠心病死亡无显著影响。
