Department of Oral and Maxillofacial Radiology, Graduate School, Kyung Hee University, Kyungheedae-ro 26, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Oral Radiol. 2020 Jan;36(1):116-120. doi: 10.1007/s11282-019-00404-2. Epub 2019 Jul 31.
Fibrous dysplasia (FD) is generally considered to be a benign disease that affects the bones, but it has potential to become malignant over time, generally several decades after its initial diagnosis. Radiation therapy can induce malignant transformation of FD; however, reports have indicated a few cases of malignant transformation of FD in the absence of radiation therapy. Angiosarcoma is a particularly rare type of cancer in the oral region, which accounts for less than 1% of all soft-tissue sarcomas. Herein, we reported a case of a 62-year-old man with monostotic FD of the left maxilla of over 50 years' duration that underwent malignant transformation into an epithelioid-type angiosarcoma. To the best of our knowledge, this is the first report of such case.
纤维结构不良（FD）通常被认为是一种良性疾病，影响骨骼，但随着时间的推移，它有可能恶变为恶性，通常在最初诊断后的几十年。放射治疗可诱导 FD 的恶性转化；然而，已有报告表明在没有放射治疗的情况下 FD 发生恶性转化的少数病例。血管肉瘤是口腔区域特别罕见的癌症类型，占所有软组织肉瘤的不到 1%。在此，我们报告了一例 62 岁男性，左侧上颌骨单骨性 FD 病史超过 50 年，恶变为上皮样型血管肉瘤。据我们所知，这是首例此类病例报告。
