乙醛脱氢酶 2 与心力衰竭。

Aldehyde Dehydrogenase 2 and Heart Failure.

机构信息

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Department of Cardiology, The Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

出版信息

Adv Exp Med Biol. 2019;1193:89-106. doi: 10.1007/978-981-13-6260-6_5.

DOI:10.1007/978-981-13-6260-6_5

PMID:31368099

Abstract

Heart failure (HF) is a structural or functional cardiac abnormal syndrome characterized with series of symptoms and signs such as breathlessness, fatigue, pulmonary crackles, and peripheral edema. Being a terminal phase of most myocardial lesions, HF has become a leading cause of mobility and mortality worldwide, associated with heavy clinical burden and economic costs affecting over 23 million people [14]. There is an increase to 5.5% with systolic dysfunction and an increase to 36.0% with diastolic dysfunction in people 60 years or older [85]. The costs accompanied with heart failure stand 2-3% of the total healthcare system expenditure in high-income countries and are expected to increase >2-fold in the next 2 decades [34].

摘要

心力衰竭（HF）是一种以呼吸困难、疲劳、肺部湿啰音和外周水肿等一系列症状和体征为特征的心脏结构或功能异常综合征。作为大多数心肌病变的终末期阶段，HF 已成为全球导致残疾和死亡的主要原因，给临床带来沉重负担，也导致了巨大的经济成本，影响了超过 2300 万人[14]。60 岁及以上人群中，收缩功能障碍的发生率增加了 5.5%，舒张功能障碍的发生率增加了 36.0%[85]。心力衰竭相关费用占高收入国家医疗保健系统总支出的 2-3%，预计在未来 20 年内将增加两倍以上[34]。