Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.
Chem Biodivers. 2019 Sep;16(9):e1900176. doi: 10.1002/cbdv.201900176. Epub 2019 Sep 17.
Type 2 diabetes is a serious metabolic disease as a long-term threat to human health. Insulin resistance is not only the basis and major feature of type 2 diabetes, but also the main etiology of diseases such as hypertension, hyperlipidemia and coronary heart disease. It has been shown that Traditional Chinese Medicines (TCMs) play an important role in the treatment of type 2 diabetes, through attenuating insulin resistance, whereas the mechanism involved is not yet well understood. Therefore, it is important to elucidate the pharmacological mechanism of these bioactive compounds so that one can pave the way for the modernization of TCMs. In this review, we focus on the recent progresses of some bioactive ingredients from TCMs with different functional groups, which exhibit therapeutic potential for the treatment of diabetic insulin resistance. It is expected that this review can provide new references for developing TCM-derived drugs against diabetes and insulin resistance in the future.
2 型糖尿病是一种严重的代谢性疾病，长期以来一直威胁着人类健康。胰岛素抵抗不仅是 2 型糖尿病的基础和主要特征，也是高血压、高血脂和冠心病等疾病的主要病因。研究表明，中药（TCM）在治疗 2 型糖尿病方面发挥着重要作用，通过减轻胰岛素抵抗，但其涉及的机制尚不清楚。因此，阐明这些生物活性化合物的药理机制非常重要，这将为 TCM 的现代化铺平道路。在这篇综述中，我们重点介绍了不同功能基团的一些 TCM 生物活性成分的最新进展，这些成分具有治疗糖尿病胰岛素抵抗的潜力。希望这篇综述能为未来开发治疗糖尿病和胰岛素抵抗的 TCM 衍生药物提供新的参考。
