Wang Chao, Shang Qinyu, Qi Rupeng, Chai Hongli, Wang Hongying, Guo Mengzhun, Xu Zhaoqing
The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University, Lanzhou, Gansu 730000, China.
Chem Commun (Camb). 2019 Aug 28;55(67):9991-9994. doi: 10.1039/c9cc04432a. Epub 2019 Aug 1.
We here report the photoinduced Cu-catalyzed cyanoalkylation of electron-deficient alkenes by using alkyl bromides as alkylation reagents. In the reactions, 1°, 2°, and 3° unactivated alkyl bromides with various sensitive functional groups were well tolerated with good yields. Notably, terminal and internal alkenes, as well as alkene-containing peptides, were all tolerated well.
我们在此报道了以溴代烷为烷基化试剂，光诱导铜催化缺电子烯烃的氰基烷基化反应。在这些反应中，带有各种敏感官能团的一级、二级和三级未活化溴代烷均能良好耐受，反应产率较高。值得注意的是，端烯和内烯以及含烯肽均能良好耐受该反应。
