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经导管主动脉瓣植入术后升主动脉直径的进展:基于计算机断层扫描图像

Progression of the Ascending Aortic Diameter After Transcatheter Aortic Valve Implantation: Based on Computed Tomography Images.

作者信息

Lv Wen-Yu, Zhao Zhen-Gang, Li Shuang-Jiang, Li Yi-Jian, Liao Yan-Biao, Ou Yuan-Weixiang, Feng Yuan, Chen Mao

机构信息

Department of Cardiology, West China Hospital, Sichuan University, #37 Guo Xue Alley, Chengdu, 610041, China.

出版信息

J Invasive Cardiol. 2019 Aug;31(8):E234-E241.

PMID:31368894
Abstract

OBJECTIVES

The natural history of ascending aortic diameter after transcatheter aortic valve implantation (TAVI) has not been investigated. Our aim was to determine the progression of ascending aortic diameter in patients undergoing TAVI.

METHODS

We retrospectively included 134 patients undergoing TAVI for aortic stenosis at our institution from June 2012 to November 2016, including 79 patients with bicuspid aortic valve (BAV) and 55 patients with tricuspid aortic valve (TAV). Preoperative measurements of the ascending aorta were compared with aortic measurements at 1-year follow-up based on computed tomography images.

RESULTS

A very slight decrease in median aortic diameter was identified in overall patients: 4.07 cm (interquartile range [IQR], 3.76-4.54 cm) vs 4.06 cm (IQR, 3.74-4.51 cm); P=.04. Further subgroup analysis found that the decrease remained statistically significant in the subgroup of TAV and mild aortic dilation. In addition, no aortic events occurred during long-term follow-up (median, 27 months; IQR, 20-42 months).

CONCLUSIONS

TAVI could prevent a further progression of aortic diameter for both BAV or TAV patients by correcting hemodynamic derangements, especially for patients with TAV, mild aortic dilation, and small annulus angles. Aortic events appeared rarely during long-term follow-up after TAVI. However, our results need further confirmation with future investigations in a larger population with longer-term follow-up.

摘要

目的

经导管主动脉瓣植入术(TAVI)后升主动脉直径的自然病程尚未得到研究。我们的目的是确定接受TAVI患者升主动脉直径的进展情况。

方法

我们回顾性纳入了2012年6月至2016年11月在我院因主动脉瓣狭窄接受TAVI的134例患者,其中包括79例二叶式主动脉瓣(BAV)患者和55例三叶式主动脉瓣(TAV)患者。根据计算机断层扫描图像,将术前升主动脉的测量值与1年随访时的主动脉测量值进行比较。

结果

总体患者的主动脉直径中位数有非常轻微的下降:4.07 cm(四分位间距[IQR],3.76 - 4.54 cm)对比4.06 cm(IQR,3.74 - 4.51 cm);P = 0.04。进一步的亚组分析发现,在TAV和轻度主动脉扩张亚组中,这种下降仍具有统计学意义。此外,在长期随访期间(中位数为27个月;IQR,20 - 42个月)未发生主动脉相关事件。

结论

TAVI可通过纠正血流动力学紊乱来预防BAV或TAV患者的主动脉直径进一步进展,特别是对于TAV、轻度主动脉扩张和小瓣环角度的患者。TAVI术后长期随访期间主动脉相关事件很少出现。然而,我们需要在更大规模人群中进行更长期随访的未来研究来进一步证实我们的结果。

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