Lamy P P, Michocki R J
School of Pharmacy, University of Maryland, Baltimore.
Clin Geriatr Med. 1988 Aug;4(3):623-38.
The elderly receive more drugs than any other patient group, and those in nursing homes receive the most. However, little is known about drug action, particularly in the very old. A host of factors can alter drug action. Particular attention needs to be paid to the influence of intercurrent disease, other drugs in a particular regimen, the patient's weight and nutritional status, as well as altered pharmacokinetic and pharmacodynamic characteristics of any drug. Liver and kidney status, and changes therein, are most important.
老年人比其他任何患者群体服用的药物都多，而养老院中的老年人服用的药物最多。然而，人们对药物作用了解甚少，尤其是对高龄老人。许多因素会改变药物作用。需要特别关注并发病、特定治疗方案中的其他药物、患者的体重和营养状况，以及任何药物药代动力学和药效学特性的改变。肝脏和肾脏状况及其变化最为重要。
